(2E)-3-(3,5-二氯苯基)丙烯酸合成路线 （共 8 条）
反应条件
malonic acid in ethanol
参考文献
Smithkline Beckman Corporation
Patent: US4707488 A1, 1987 ;
反应条件
hydrogenchloride in tetrahydrofuran; water
参考文献
Novartis AG; Legrand, Darren Mark; Furminger, Vikki; Thomson, Christopher; Hughes, Owen Rhys; Stanley, Emily
Patent: US2014/171403 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
piperidine 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h;
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
sodium acetate T=180 - 210°C;
参考文献
Asinger; Lock
Monatshefte fuer Chemie, 1933 , vol. 62, p. 344,347
反应条件
1: triethylamine / N,N-dimethyl-formamide 2: hydrogenchloride / tetrahydrofuran; water View Scheme
参考文献
Novartis AG; Legrand, Darren Mark; Furminger, Vikki; Thomson, Christopher; Hughes, Owen Rhys; Stanley, Emily
Patent: US2014/171403 A1, 2014 ;
反应条件
1: H2 / platinum oxide / aq. ethanol 2: oxalyl chloride / CH2Cl2 / 20 °C 3: aluminum chloride / CH2Cl2 / Heating View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=2585.7 Torr; 5 h;
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 95 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
2: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
