4-氯-4,4-二氟乙酰乙酸乙酯合成路线 （共 9 条）
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-70 - -20°C; 2.08333 h; 2: ethyl acetate; Chlorodifluoroacetic acid in tetrahydrofuran; hexane T=-70 - -60°C; 4.33333 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water T=-5 - 20°C; 16 h;
参考文献
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Patent: WO2005/3077 A1, 2005 ;
Location in patent: Page 12 ;
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-70 - 20°C; Claisen Condensation; 4.5 h;
参考文献
SOLVAY SA; BRAUN, Max Josef; JAUNZEMS, Janis; KASUBKE, Michael
Patent: WO2012/25469 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1: methyleneoxaethylene; difluorochloroacetyl chloride in dichloromethane T=-30 - 0°C; 3 h; 2: ethanol in dichloromethane T=5°C;
参考文献
SOLVAY FLUOR GmbH; BRAUN, Max
Patent: WO2010/94746 A2, 2010 ;
Location in patent: Page/Page column 6-7 ;
反应条件
lithium diisopropyl amide in diethyl ether T=-70°C; 4 h;
参考文献
Kitazume, Tomoya; Asai, Masatomo; Tsukamoto, Takashi; Yamazaki, Takashi
Journal of Fluorine Chemistry, 1992 , vol. 56, # 3 p. 271 - 284
参考文献
SOLVAY (SOCIETE ANONYME)
Patent: WO2009/21987 A1, 2009 ;
Location in patent: Page/Page column 4 ;
反应条件
1: ethyl acetate With n-butyllithium; diisopropylamine in diethyl ether T=-75°C; 0.333333 h; 2: ethyl chloro-difluoroacetate in diethyl ether T=-75°C; 3 h;
参考文献
Golubev; Starostin; Chunikhin; Peregudov; Rodygin; Rubtsova; Slepukhin; Kuchin; Chkanikov
Russian Chemical Bulletin, 2011 , vol. 60, # 4 p. 733 - 745
参考文献
SOLVAY (SOCIETE ANONYME)
Patent: WO2009/21987 A1, 2009 ;
Location in patent: Page/Page column 4 ;
反应条件
1: acetic anhydride / 7 h / 120 - 140 °C 2: SOLKANE 365 mfc / 1 h / 20 °C / Cooling with ice 3: cesium fluoride; zinc / ethanol; water / 6 h View Scheme
参考文献
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Patent: WO2005/3077 A1, 2005 ;
Location in patent: Page 11 ;
