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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
207220-30-2
合成路线
（共 10 条）
→
反应条件
207220-30-2
反应条件
I2; CuI in tetrahydrofuran
参考文献
Weigele, Manfred; Sawyer, Tomi K.; Bohacek, Regine; Shakespeare, William C.; Sundaramoorthi, Rajeswari; Wang, Yihan; Dalgarno, David C.; Metcalf III, Chester A.
Patent: US2002/68721 A1, 2002 ;
244030-28-2
→
反应条件
207220-30-2
反应条件
copper(l) iodide; diiodomethane in tetrahydrofuran Heating;
参考文献
Legraverend, Michel; Ludwig, Odile; Bisagni, Emile; Leclerc, Sophie; Meijer, Laurent; Giocanti, Nicole; Sadri, Ramin; Favaudon, Vincent
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 7 p. 1281 - 1293
67-63-0
异丙醇
+
18552-90-4
2-碘-6-氯嘌呤
→
反应条件
207220-30-2
反应条件
1: 6-chloro-2-iodo-(9H)-purine With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=-50°C; 0.166667 h; 2: isopropyl alcohol in tetrahydrofuran T=20°C; 48 h;
参考文献
Brun, Virginie; Legraverend, Michel; Grierson, David S
Tetrahedron, 2002 , vol. 58, # 39 p. 7911 - 7923
67-63-0
异丙醇
+
1972-28-7
偶氮二甲酸二乙酯
+
18552-90-4
2-碘-6-氯嘌呤
→
反应条件
4114-28-7
肼二羧酸二乙酯
+
207220-30-2
反应条件
triphenylphosphine in tetrahydrofuran T=-30°C; Title compound not separated from byproducts.;
参考文献
Taddei, David; Kilian, Petr; Slawin, Alexandra M.Z.; Woollins, J. Derek
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 5 p. 665 - 670
403620-89-3
→
反应条件
207220-30-2
反应条件
1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 2: Ph3P / tetrahydrofuran / -30 °C View Scheme
参考文献
Brun, Virginie; Legraverend, Michel; Grierson, David S
Tetrahedron, 2002 , vol. 58, # 39 p. 7911 - 7923
68-94-0
次黄嘌呤
→
反应条件
207220-30-2
反应条件
1.1: 86 percent / POCl3 / N,N-dimethyl-acetamide / 2 h / 120 °C 2.1: 68 percent / p-TsOH / tetrahydrofuran / 80 °C 3.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / -78 °C 3.2: Bu3SnCl / hexane; tetrahydrofuran / 1 h / -78 °C 3.3: 8.0 g / iodine / tetrahydrofuran / 24 h 4.1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 5.1: Ph3P / tetrahydrofuran / -30 °C View Scheme
参考文献
Taddei, David; Kilian, Petr; Slawin, Alexandra M.Z.; Woollins, J. Derek
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 5 p. 665 - 670
87-42-3
6-氯嘌呤
→
反应条件
207220-30-2
反应条件
1.1: 68 percent / p-TsOH / tetrahydrofuran / 80 °C 2.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / -78 °C 2.2: Bu3SnCl / hexane; tetrahydrofuran / 1 h / -78 °C 2.3: 8.0 g / iodine / tetrahydrofuran / 24 h 3.1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 4.1: Ph3P / tetrahydrofuran / -30 °C View Scheme
参考文献
Taddei, David; Kilian, Petr; Slawin, Alexandra M.Z.; Woollins, J. Derek
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 5 p. 665 - 670
7306-68-5
6-氯-9-(四氢-2-吡喃基)嘌呤
→
反应条件
207220-30-2
反应条件
1.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: Bu3SnCl / hexane; tetrahydrofuran / 1 h / -78 °C 1.3: 8.0 g / iodine / tetrahydrofuran / 24 h 2.1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 3.1: Ph3P / tetrahydrofuran / -30 °C View Scheme
参考文献
Brun, Virginie; Legraverend, Michel; Grierson, David S
Tetrahedron, 2002 , vol. 58, # 39 p. 7911 - 7923
343327-12-8
→
反应条件
207220-30-2
反应条件
1: conc. HCl / N,N-dimethyl-acetamide / Ambient temperature 2: 82 percent / CH2I2, CuI / tetrahydrofuran / Heating View Scheme
参考文献
Legraverend, Michel; Ludwig, Odile; Bisagni, Emile; Leclerc, Sophie; Meijer, Laurent; Giocanti, Nicole; Sadri, Ramin; Favaudon, Vincent
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 7 p. 1281 - 1293
109-85-3
2-甲氧基乙胺
+
207220-30-2
→
反应条件
897040-21-0
反应条件
triethylamine in ethanol T=60°C; 48 h;
参考文献
Vandromme, Lucie; Legraverend, Michel; Kreimerman, Sergio; Lozach, Olivier; Meijer, Laurent; Grierson, David S.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 130 - 141
