反应条件
1: piperidine; (R)-2-phenyloxirane in ethanol T=80°C; 5 h; 2: methanesulfonyl chloride With triethylamine in tert-butyl methyl ether T=-18 - -10°C; 3: 1,3-diamino-propane; Methanesulfonate(S)-1-phenyl-3-azonia-spiro[2.5]octane; in water T=20°C; 1 h;
参考文献
Frizzle, Matthew J.; Caille, Sebastien; Marshall, Teresa L.; McRae, Kenneth; Nadeau, Kelly; Guo, Gary; Wu, Steven; Martinelli, Michael J.; Moniz, George A.
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 215 - 222
