2-(2-氯乙酰基氨基)-4,5,6,7-四氢苯并[b]噻吩-3-羧酸胺合成路线 （共 4 条）
反应条件
triethylamine T=0 - 20°C; 2 h;
参考文献
PROTEOSTASIS THERAPEUTICS, INC.; CHAMBERS, Robert, J.; FOLEY, Megan; TAIT, Bradley
Patent: WO2013/112651 A2, 2013 ;
Location in patent: Page/Page column 64 ;
参考文献
Ismail, Mohamed M.; Kamel, Mona M.; Mohamed, Lamia W.; Faggal, Samar I.; Galal, Mai A.
Molecules, 2012 , vol. 17, # 6 p. 7217 - 7231
反应条件
1: 80 percent / sulfur; diethyl amine / 20 - 58 °C 2: 71 percent / pyridine / benzene View Scheme
参考文献
Ismail, Mohamed M.; Kamel, Mona M.; Mohamed, Lamia W.; Faggal, Samar I.; Galal, Mai A.
Molecules, 2012 , vol. 17, # 6 p. 7217 - 7231
反应条件
polyphosphate ester
8 h; Heating;
参考文献
Kanwar, Seema; Sharma
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371
