2-甲基环丙烷-1-甲酸乙酯合成路线 （共 11 条）
反应条件
sodium hydride in tetrahydrofuran 8 h; Heating;
参考文献
Krawczyk, Henryk; Wasek, Katarzyna; Kedzia, Jacek
Synlett, 2005 , # 17 art. no. G24105ST, p. 2648 - 2652
反应条件
in 1,4-dioxane 12 h; Heating; Yield given;
参考文献
Journal of the American Chemical Society, , vol. 109, p. 3739
反应条件
1: 84 percent / 5 h / 140 °C 2: 56 percent / NaH / tetrahydrofuran / 8 h / Heating View Scheme
参考文献
Synlett, , # 17 art. no. G24105ST, p. 2648 - 2652
反应条件
1: 60 percent / Br2; PBr3 / 25 h / 100 °C 2: 84 percent / 5 h / 140 °C 3: 56 percent / NaH / tetrahydrofuran / 8 h / Heating View Scheme
参考文献
Synlett, , # 17 art. no. G24105ST, p. 2648 - 2652
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Tetrahedron, , vol. 51, # 3 p. 657 - 664
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Heating;
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 1735 - 1739
反应条件
potassium hydroxide in methanol Heating;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/103185 A2, 2008 ;
Location in patent: Page/Page column 19 ;
WO 2008/103185 A2
反应条件
hydrogen; palladium on activated charcoal T=100°C; P=110326 Torr; 1.2 h; the formed products are detected with gas chromatography; Product distribution;
参考文献
Liebigs Annalen der Chemie, , # 7 p. 1485 - 1491
反应条件
1: With sodium hydroxide; water T=46°C; 1 - 4 h; 2: With hydrogenchloride in water Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/103185 A2, 2008 ;
Location in patent: Page/Page column 16-17 ;
WO 2008/103185 A2
反应条件
hydrogen; palladium on activated charcoal T=100°C; P=110326 Torr; 1.2 h; the formed products are detected with gas chromatography; Product distribution;
参考文献
Liebigs Annalen der Chemie, , # 7 p. 1485 - 1491
