2,3,4-三甲氧基苯甲醛合成路线 （共 87 条）
反应条件
1: AcOOH, HClO4, Ac2O
2: KOH / ethanol / Heating
3: K2CO3 / acetone; benzene
4: AlCl3 / CS2 / Heating
5: K2CO3 / acetone; dimethylformamide / Heating
View Scheme
参考文献
Huee,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3617 - 3624
反应条件
ammonium hydroxide; Fremy’s salt in pyridine
192 h; Ambient temperature;
参考文献
Llobera, A.; Saa, J. M.; Peralta, A.
Synthesis, 1985 , # 1 p. 95 - 98
反应条件
sodium hydroxide in ethanol
T=5 - 20°C; Claisen Schmidt condensation;
参考文献
Kumar, Dileep; Harish; Gangwar, Mayank; Kumar, Manish; Kumar, Dharmendra; Tilak, Ragini; Nath, Gopal; Kumar, Ashok; Singh, Sushil Kumar
Letters in Drug Design and Discovery, 2013 , vol. 10, # 2 p. 119 - 128
反应条件
ammonium acetate; acetic acid
T=100°C; 12 h;
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
反应条件
in diethyl ether
1 h; Molecular sieve;
参考文献
Kivrak, Arif; Larock, Richard C.
Journal of Organic Chemistry, 2010 , vol. 75, # 21 p. 7381 - 7387
反应条件
nitric acid; acetic acid
T=0°C; 1.5 h; Inert atmosphere;
参考文献
Carreras, Javier; Gopakumar, Gopinadhanpillai; Gu, Liangu; Gimeno, Ana; Linowski, Pawel; Petuskova, Jekaterina; Thiel, Walter; Alcarazo, Manuel
Journal of the American Chemical Society, 2013 , vol. 135, # 50 p. 18815 - 18823
反应条件
ammonium acetate in acetic acid
Heating;
参考文献
Shulgin
Journal of medicinal chemistry, 1966 , vol. 9, # 3 p. 445 - 446
反应条件
1: AcOH / ethanol / 18 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 98 percent / Ac2O / 1 h / 70 °C
4: 97 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature
5: 99 percent / TFAA, BF3*OEt2 / benzene / 1 h / Ambient temperature
6: 76 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
7: 86 percent / 10 percent NaOH / H2O; ethanol / 1.5 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Kohno, Michiyo; Sano, Takehiro
Heterocycles, 1999 , vol. 51, # 1 p. 119 - 129
反应条件
sodium cyanoborohydride; acetic acid
16 h; Ambient temperature;
参考文献
Ferte, Jacques; Kuehnel, Jean-Marc; Chapuis, Genevieve; Rolland, Yves; Lewin, Guy; Schwaller, Marc A.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 478 - 489
反应条件
in benzene
4 h; Heating;
参考文献
Ioanoviciu, Alexandra; Antony, Smitha; Pommier, Yves; Staker, Bart L.; Stewart, Lance; Cushman, Mark
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 4803 - 4814
