2,3,4-三甲氧基苯甲醛合成路线 （共 87 条）
反应条件
1: Methyltriphenylphosphonium bromide With sodium amide in diethyl ether
T=20°C; 10 h; Inert atmosphere;
2: 2,3,4-trimethoxy-benzaldehyde in diethyl ether
T=-10 - 20°C; Wittig reaction; Inert atmosphere;
参考文献
Sun, Bin; Hoshino, Juma; Jermihov, Katie; Marler, Laura; Pezzuto, John M.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5352 - 5366
反应条件
2: KHSO4
View Scheme
参考文献
Sapewalowa; Koton
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2900,2902; engl. Ausg. S. 2860, 2862
参考文献
Sapewalowa; Koton
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2900,2902; engl. Ausg. S. 2860, 2862
反应条件
pyridine in ethanol; dichloromethane; water; ethyl acetate
参考文献
Zaveri, Nurulain; Chao, Wan-Ru
Patent: US2004/29914 A1, 2004 ;
反应条件
1: 51 percent / NaH / dimethylsulfoxide / 16 h / 50 °C
2: H2 / Pd/C / ethanol / 48 h / 20 °C
View Scheme
参考文献
Kranich, Remo; Busemann, Anke S.; Bock, Daniel; Schroeter-Maas, Sabine; Beyer, Diana; Heinemann, Bo; Meyer, Michael; Schierhorn, Katrin; Zahlten, Rainer; Wolff, Gerhard; Aydt, Ewald M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1101 - 1115
反应条件
1: 50 percent / NaBH3CN / tetrahydrofuran
2: BCl3 / CH2Cl2 / 2.5 h
View Scheme
参考文献
Lambert, Maja; Olsen, Lars; Jaroszewski, Jerzy W.
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9449 - 9457
反应条件
copper quinolate; tetra-(n-butyl)ammonium iodide in water; dimethyl sulfoxide
T=120°C; 24 h;
参考文献
Zhu, Yan; Yan, Hong; Lu, Linhua; Liu, Defu; Rong, Guangwei; Mao, Jincheng
Journal of Organic Chemistry, 2013 , vol. 78, # 19 p. 9898 - 9905
