2-溴-1-(4-甲氧苯基)丙酮合成路线 （共 18 条）
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C 2: hydrogenchloride / ethanol; ethyl acetate / 1 h / 20 °C 3: AlCl3, aluminium chloride; aluminum isopropoxide / isopropyl alcohol / 12 h / 65 °C View Scheme
参考文献
Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 123 - 136
反应条件
[Ru(II)(2,2’-bipyridine)3]Cl2; DNP; ascorbic acid powder in methanol; water 24 h; Inert atmosphereIrradiation;
参考文献
Journal of Organic Chemistry, , vol. 76, # 2 p. 736 - 739
参考文献
Justus Liebigs Annalen der Chemie, , vol. 535, p. 219,248
反应条件
zinc dibromide
T=115°C; 4 h;
参考文献
Giordano, Claudio; Castaldi, Graziano; Casagrande, Francesco; Abis, Luigi
Tetrahedron Letters, 1982 , vol. 23, # 13 p. 1385 - 1386
反应条件
1: N,N-dimethylaniline / 170 °C
2: 1.) Na/liquid NH3 / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min
3: BBr3 / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Angerer, Erwin von; Prekajac, Jelica; Strohmeier, Josef
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1439 - 1447
反应条件
1: N,N-dimethylaniline / 170 °C
2: 1.) Na/liquid NH3 / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min
3: BBr3 / CH2Cl2 / -60 - 20 °C
4: pyridine / 2 h / Heating
View Scheme
参考文献
Angerer, Erwin von; Prekajac, Jelica; Strohmeier, Josef
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1439 - 1447
反应条件
methanesulfonic acid in methanol
参考文献
Giordano, Claudio; Castaldi, Graziano; Casagrande, Francesco; Belli, Aldo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 11 p. 2575 - 2582
反应条件
N,N-dimethyl-aniline in xylene
T=180°C; 2 h;
参考文献
Brunner; Nerl; Angerer; Knebel
Archiv der Pharmazie, 1991 , vol. 324, # 10 p. 779 - 784
