N,N-二甲基喹啉-2-胺合成路线 （共 14 条）
参考文献
Luthy et al.
Journal of Organic Chemistry, 1949 , vol. 14, p. 322,325, 326
反应条件
sodium t-butanolate in tetrahydrofuran; toluene
T=65°C; Buchwald-Hartwig amination; 18 h; Inert atmosphereSealed vial;
参考文献
Lundgren, Rylan J.; Sappong-Kumankumah, Antonia; Stradiotto, Mark
Chemistry - A European Journal, 2010 , vol. 16, # 6 p. 1983 - 1991
参考文献
Watanabe, Tokuhiro; Tanaka, Yukiko; Sekiya, Kohko; Akita, Yasuo; Ohta, Akihiro
Synthesis, 1980 , # 1 p. 39 - 41
反应条件
ammonia in water
T=240°C; 0.5 h;
参考文献
Petersen, Trine P.; Larsen, Anders Foller; Ritzen, Andreas; Ulven, Trond
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4190 - 4195
反应条件
in dimethyl sulfoxide
T=50°C;
参考文献
Poola, Bhaskar; Choung, Wonken; Nantz, Michael H.
Tetrahedron, 2008 , vol. 64, # 48 p. 10798 - 10801
反应条件
N,N,N',N,-tetramethylethylenediamine in toluene
T=-40 - 20°C; Substitution; 1.5 h;
参考文献
Haase, Mirko; Guenther, Wolfgang; Goerls, Helmar; Anders, Ernst
Synthesis, 1999 , # 12 p. 2071 - 2081
参考文献
Gupton, John T.; Idoux, John P; Baker, Graeme; Colon, Cesar; Crews, A.Donald; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 17 p. 2933 - 2936
反应条件
Pd catalyst
Buchwald-Hartwig Coupling; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Michigami, Kenichi; Sato, Yoshihiro
Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 2970 - 2973
参考文献
Gilman et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 2106
反应条件
1: acetonitrile / 0.5 h / 0 °C
2: NaI / acetonitrile / 0.17 h / 50 °C
3: 63 percent / Et3N / CH2Cl2 / 2 h / 20 °C
4: 8 percent / TMEDA / toluene / 1.5 h / -40 - 20 °C
View Scheme
参考文献
Haase, Mirko; Guenther, Wolfgang; Goerls, Helmar; Anders, Ernst
Synthesis, 1999 , # 12 p. 2071 - 2081
