1: 93 percent / ImH / dimethylformamide / Ambient temperature 2: 80 percent / DIBAL / diethyl ether; hexane / 0.33 h / -78 °C 3: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C 4: NEt3 / CH2Cl2 / Ambient temperature 5: 70 percent / HCl 6: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 7: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 8: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme

暂无反应条件数据

1: LAH / tetrahydrofuran / 1 h / 0 °C 2: Et3N / CH2Cl2 / 3 h / 20 °C View Scheme

1: 1.) Mg, I2 / 1.) THF, reflux, 3 h; 2.) THF, reflux, 3-5 h 2: pyridine / CH2Cl2 / 2 h / Ambient temperature View Scheme

1: With recombinant Alcaligenes faecalis penicillin G acylase immobilized on oxirane acrylic carrier; potassium hydroxide in water T=35°C; pH=10; 5.33333 h; Enzymatic reaction; 2: With hydrogenchloride in water pH=1; optical yield given as percent eeenantioselective reaction;

1,4-diaza-bicyclo[2.2.2]octane in dimethyl sulfoxide T=130°C; Racemization; Kinetics;

triethylamine; tris(triphenylphosphine)ruthenium(II) chloride in toluene T=50°C; Racemization; 24 h; Product distribution; Further Variations:CatalystsReagentsSolventsTemperatures;

in dichloromethane T=23°C; 1.08333 h; Inert atmosphere;

lithium aluminium tetrahydride in ethylene glycol dimethyl ether T=0 - 20°C; Inert atmosphere;

1: AgO, CaSO4 2: H2SO4 View Scheme