1-溴-2-苯基乙炔-苯合成路线 （共 49 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; cesium fluoride in 1,4-dioxane
T=130 - 140°C;
参考文献
Levi, Zerubba U.; Tilley, T. Don
Journal of the American Chemical Society, 2009 , vol. 131, p. 2796 - 2797
反应条件
1: 1) t-BuLi / 2) -78 deg C up to 25 deg C, 12 h
2: 70 percent / KOH, <18>-crown-6 / benzene / 24 h / Ambient temperature; other phosphinotolanes
3: 1) dioxane*Br2 / 1) CHCl3
View Scheme
参考文献
Markl; Jin; Berr
Tetrahedron Letters, 1993 , vol. 34, # 19 p. 3103 - 3106
反应条件
1: (i) nBuLi, (ii) B(OnBu)3
2: aq. H2O2 / acetic acid; ethanol
View Scheme
参考文献
Letsinger,R.L. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1271 - 1273
反应条件
1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
2: 3.72 g / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Matsuda, Takanori; Kadowaki, Sho; Goya, Tsuyoshi; Murakami, Masahiro
Organic Letters, 2007 , vol. 9, # 1 p. 133 - 136
反应条件
1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
2: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Matsuda, Takanori; Kadowaki, Sho; Goya, Tsuyoshi; Murakami, Masahiro
Organic Letters, 2007 , vol. 9, # 1 p. 133 - 136
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in toluene
T=105°C; 24 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Potukuchi, Harish K.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 7-8 p. 1064 - 1072
反应条件
1: With 1,1'-bis-(diphenylphosphino)ferrocene; [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate in toluene
T=20 - 105°C; Inert atmosphereCombinatorial reaction / High throughput screening (HTS);
2: With potassium tert-butylate in toluene
T=20 - 120°C; Inert atmosphereCombinatorial reaction / High throughput screening (HTS);
参考文献
Ackermann, Lutz; Song, Weifeng; Sandmann, Rene
Journal of Organometallic Chemistry, 2011 , vol. 696, # 1 p. 195 - 201
反应条件
tri-tert-butyl phosphine; potassium tert-butylate; palladium diacetate in toluene
T=110 - 120°C; 14 h;
参考文献
Tang, Zhen-Yu; Hu, Qiao-Sheng
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 7-8 p. 846 - 850
反应条件
Pyridine-2-carbaldehyde oxime; ammonia; copper(II) bis(trifluoromethanesulfonate); potassium carbonate in water; dimethyl sulfoxide
T=100°C; 18 h; Inert atmosphere;
参考文献
Wang, Huifeng; Li, Yaming; Jiang, Linlin; Zhang, Rong; Jin, Kun; Zhao, Defeng; Duan, Chunying
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4983 - 4986
