3,5-二甲氧基苯甲酸甲酯合成路线 （共 80 条）
反应条件
N'',N'''''-1,8-naphthalenediyl-bis[N,N,N',N'-tetramethyl]-guanidine in N,N-dimethyl-formamide T=20°C; Kinetics;
参考文献
Organic Process Research and Development, , vol. 16, # 5 p. 811 - 818
反应条件
T=200°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemische Berichte, , vol. 120, p. 1339 - 1346
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 47, # 3 p. 167 - 174
反应条件
1: 3,4-dihydroxy-benzoic acid; 2,4-dihydroxy-benzoic acid; 3,4,5-trihydroxybenzenoic Acid; 3,5-di(hydroxy)benzoic acid; 2,3-dihydroxy-benzoic acid; 2,5-dihydroxyphenylcarboxylic acid; meta-hydroxy benzoic acid; salicylic acid; 4-hydroxy-benzoic acid With sodium hydride in hexane; N,N-dimethyl-formamide T=25°C; 2 h; Inert atmosphereCooling with ice; 2: methyl iodide in hexane; N,N-dimethyl-formamide 72 h; Inert atmosphere;
参考文献
Chemical Communications, , vol. 50, # 14 p. 1694 - 1697
参考文献
Acta Phytochimica, , vol. 11, p. 167,179
参考文献
Monatshefte fuer Chemie, , vol. 29, p. 663
反应条件
1: lithium aluminium tetrahydride / diethyl ether / 6 h / 20 °C / |Inert atmosphere 2: Dess-Martin periodane / dichloromethane / 0 °C / |Inert atmosphere 3: Methyltriphenylphosphonium bromide; sodium hydride / tetrahydrofuran; mineral oil / 20 °C / |Inert atmosphere 4: sodium acetate; palladium diacetate / methanol / 12 h / 20 °C / |Inert atmosphere View Scheme
参考文献
McNulty, James; McLeod, David
Tetrahedron Letters, 2013 , vol. 54, # 47 p. 6303 - 6306
反应条件
in diethyl ether Ambient temperature;
参考文献
Vakalopoulos, Alexandros; Schmeck, Carsten; Thutewohl, Michael; Li, Volkhart; Bischoff, Hilmar; Lustig, Klemens; Weber, Olaf; Paulsen, Holger; Elias, Harry
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 488 - 491
反应条件
magnesium 1.) ether, reflux, 0.5 h, 2.) ether, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Hartmann, Rolf W.; Kranzfelder, Gerhard; Angerer, Erwin, v.; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 841 - 848
反应条件
1: With naphthalenyllithium in tetrahydrofuran T=20°C; 1 h; 2: With chloro-trimethyl-silane in tetrahydrofuran T=-78°C; 0.5 h; 3: With water in tetrahydrofuran T=0°C; Title compound not separated from byproducts;
参考文献
Bayardon, Jerome; Sinou, Denis
Synthesis, 2005 , # 3 art. no. Z19104SS, p. 425 - 428
