1,3-二噻烷-2-基(苯基)甲酮合成路线 （共 18 条）
反应条件
in tetrahydrofuran; hexane
-78 deg C to room t.;
参考文献
Page, Philip C. Bulman; van Niel, Monique B.; Westwood, Donald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 269 - 276
反应条件
1: 67 percent / benzene / 16 h / 55 °C
2: 40 percent / KOH / tetrahydrofuran; H2O / 10 h / 0 °C
View Scheme
参考文献
Hiroi; Sato; Matsuo
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 2 p. 558 - 566
反应条件
1: 34 percent / Pb(OAc)4 / benzene / 16 h / 55 °C
2: 40 percent / KOH / tetrahydrofuran; H2O / 10 h / 0 °C
View Scheme
参考文献
Hiroi; Sato; Matsuo
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 2 p. 558 - 566
反应条件
in tetrahydrofuran; hexane
-78 deg C to room t.;
参考文献
Page, Philip C. Bulman; van Niel, Monique B.; Westwood, Donald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 269 - 276
反应条件
n-butyllithium
1.) hexane, THF, -20 deg, 2.5 h 2.) hexane, THF, -78 deg C, 2.5 h; Yield given. Multistep reaction;
参考文献
Hiroi; Sato; Matsuo
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 2 p. 558 - 566
反应条件
water; silica gel
1.) THF, hexane, -78 deg C to room t.; Yield given. Multistep reaction;
参考文献
Page, Philip C. Bulman; van Niel, Monique B.; Westwood, Donald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 269 - 276
反应条件
water; silica gel
1.) THF, hexane, -78 deg C to room t.; Yield given. Multistep reaction;
参考文献
Page, Philip C. Bulman; van Niel, Monique B.; Westwood, Donald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 269 - 276
反应条件
1: tetrahydrofuran / 2 h / 15 - 20 °C / Inert atmosphere
2: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
3: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
4: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
5: triethylamine / dichloromethane / 0 - 20 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
