1-溴-2,4,6-三异丙苯合成路线 （共 33 条）
反应条件
1-(p-toluenebenzenesulfonyloxy)-1,2-benziodoxol-3(1H)-on; tetrabutylammomium bromide in acetonitrile 16 h; Ambient temperatureother reagents (trivalent iodine compounds + LiBr or Bu4NBr), other reagent ratio; Product distribution;
参考文献
Muraki, Takahito; Togo, Hideo; Yokoyama, Masataka
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2883 - 2889
反应条件
methanol; water; bromine Bromination of starting compd.;
参考文献
Smith, Keith; Pelter, Andrew; Jin, Zhao
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 4 p. 395 - 396
反应条件
1: AlCl3, aluminium chloride / -40 - 20 °C / |Inert atmosphere 2: bromine / chloroform / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 35 p. 9266 - 9270
Angew. Chem., , vol. 125, # 35 p. 9436 - 9440
反应条件
T=0°C; Lichtausschluss;
参考文献
Journal of the American Chemical Society, , vol. 62, p. 2962
Journal of the American Chemical Society, , vol. 65, p. 2444
反应条件
1: 2-bromo-1,3,5-triisopropylbenzene With magnesium; ethylene dibromide in tetrahydrofuran 1.5 h; Inert atmosphereReflux; 2: 1,4-dimethoxy-2-fluorobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere; 3: With iodine in tetrahydrofuran; hexane T=0 - 20°C; 1.25 h; Inert atmosphere; Product distribution / selectivity;
参考文献
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Patent: WO2009/76622 A2, 2009 ;
Location in patent: Page/Page column 139-140 ;
反应条件
magnesium in tetrahydrofuran
参考文献
Wu, Xiaoxing; Fors, Brett P.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 42 p. 9943 - 9947
反应条件
diethyl ether; phenyllithium anschliessend Behandeln mit CO2;
参考文献
Fuson; Horning
Journal of the American Chemical Society, 1940 , vol. 62, p. 2962
反应条件
(i) tBuLi, THF, hexane, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Beak, Peter; Carter, Linda G.
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2363 - 2373
参考文献
Fuson; Horning
Journal of the American Chemical Society, 1940 , vol. 62, p. 2962
反应条件
1: 2-bromo-1,3,5-triisopropylbenzene With magnesium; ethylene dibromide in tetrahydrofuran T=65°C; 1 h; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=65°C; 1 h; 3: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran T=20°C; 20 h;
参考文献
Liu, Lei; Wu, Hai-Chen; Yu, Jin-Quan
Chemistry - A European Journal, 2011 , vol. 17, # 39 p. 10828 - 10831
