hydrogenchloride 7 h; Heating;

hydrogenchloride

1: 1-bromocyclohexane With chloro-trimethyl-silane; magnesium; ethylene dibromide; lithium chloride; zinc dibromide in tetrahydrofuran T=25°C; 2 h; Inert atmosphere; 2: 4-EtO2CC6H4N2BF4 in tetrahydrofuran T=-60 - 25°C; Inert atmosphere; 3: With chloro-trimethyl-silane in tetrahydrofuran T=125°C; 0.5 h; Inert atmosphereMicrowave irradiation; regioselective reaction;

in 2-methoxy-ethanol T=130°C; 12 h; Inert atmosphere;

1: N-bromosuccinmide; ammonium acetate / diethyl ether / 0.5 h / 20 °C 2: 2-methoxy-ethanol / 12 h / 130 °C / |Inert atmosphere View Scheme

1: 97.6 percent / 5 percent Pd/C / xylene / 40 h / Heating 2: 92 percent / KOH / ethanol; H2O / 5 h / Heating View Scheme