2-甲基-2-苯基丙烷-1-醇合成路线 （共 48 条）
反应条件
thionyl chloride
T=0°C;
参考文献
Haller; Bauer
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1912 , vol. 155, p. 1583
Annales de Chimie (Cachan, France), 1918 , vol. <9> 9, p. 10
参考文献
Haller; Ramart
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1922 , vol. 174, p. 1212
反应条件
1: 72 percent / NaH / dimethylsulfoxide / 3 h / 60 °C
2: H2 / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature
3: 1.) 33percent NaNO2/H2O, conc. HCl, ethyl acrylate, 2.) Cu2O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h
View Scheme
参考文献
Takeda
Patent: DE2625163 , 1976 ;
Chem.Abstr., 1977 , vol. 86, # 171117
反应条件
sodium hydride in dimethyl sulfoxide
T=60°C; 3 h;
参考文献
Kawamatsu; Asakawa; Saraie; Mizuno; Imamiya; Nishikawa; Hamuro
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 751 - 758
反应条件
1: 72 percent / NaH / dimethylsulfoxide / 3 h / 60 °C
2: H2 / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Takeda
Patent: DE2625163 , 1976 ;
Chem.Abstr., 1977 , vol. 86, # 171117
反应条件
sulfur trioxide pyridine complex; triethylamine in dimethyl sulfoxide
T=20°C; 2.5 h;
参考文献
NOVO NORDISK A/S
Patent: WO2008/84044 A1, 2008 ;
Location in patent: Page/Page column 117 ;
WO 2008/084044 A1
反应条件
sodium chloride; triethylamine in dichloromethane; water
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US4987132 A1, 1991 ;
反应条件
2-Bromo-1,3,5-trimethyl-benzene; potassium carbonate; palladium diacetate; triphenylphosphine in ethylene glycol dimethyl ether
T=85°C; 10 h; Yield given. Yields of byproduct given;
参考文献
Tamaru, Yoshinao; Yamada, Yoshimi; Inoue, Kenji; Yamamoto, Youichi; Yoshida, Zen-ichi
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1286 - 1292
