2,4-二氨基-5-(3-氨基-4-氯-5-硝基苯基)-6-乙基嘧啶合成路线 （共 15 条）
参考文献
British Technology Group Limited
Patent: US5618928 A1, 1997 ;
反应条件
sulfuric acid; nitric acid T=50°C; 1 h;
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
反应条件
sulfuric acid; nitric acid
参考文献
FMC Corporation
Patent: US5521192 A1, 1996 ;
反应条件
hydrogenchloride in ethanol T=60°C; 12 h;
参考文献
Griffin, Roger J.; Lowe, Philip R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 14 p. 1811 - 1820
反应条件
sodium tungstate; dihydrogen peroxide in methanol 12 h; Ambient temperature;
参考文献
Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 22 p. 3311 - 3318
参考文献
Griffin, Roger J.; Meek, Michelle A.; Schwalbe, Carl H.; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2468 - 2474
反应条件
1: SnCl2*2H2O / ethanol / Heating 2: 1.) NaNO2, 5M aq. HCl; 2.) NaN3 / 1.) 0 deg C; 2.) 0 deg C, 2 h 3: 85 percent / 98percent hydrazine hydrate / 0.25 h / Heating View Scheme
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
参考文献
Griffin, Roger J.; Meek, Michelle A.; Schwalbe, Carl H.; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2468 - 2474
反应条件
1: 93 percent / acetic acid / 0.5 h / Heating 2: 87 percent / SnCl2 / ethanol / 70 °C 3: HCl / ethanol / 12 h / 60 °C 4: 80 percent / acetic acid / 1 h / 100 °C 5: ZnCl2 / ethanol / Ambient temperature View Scheme
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
反应条件
1: SnCl2*2H2O / ethanol / Heating 2: 4.9 g / 1.) reflux, 4 h; 2.) EtOH, 25 deg C, 4 weeks View Scheme
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
