7,8-二氢-6H-异喹啉-5-酮合成路线 （共 9 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-60 - -50°C; 0.333333 h; 2: With triethylamine in dichloromethane T=-60 - 20°C; 0.0833333 h;
参考文献
PALAU PHARMA, S. A.
Patent: WO2007/60198 A1, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/060198 A1
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in o-di-fluorobenzene; dimethyl sulfoxide T=85°C; 24 h;
参考文献
Nicolaou; Baran; Zhong
Journal of the American Chemical Society, 2001 , vol. 123, # 13 p. 3183 - 3185
反应条件
chromium(VI) oxide; sulfuric acid; acetic acid in water T=15 - 20°C; 5 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 31 - 35
反应条件
sodium hydrogencarbonate in water
参考文献
EP1726590 A1, ;
Page/Page column 35 ;
反应条件
potassium permanganate in water; acetic acid 0.583333 h;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 22 p. 3381 - 3385
反应条件
1: 1.) acetic anhydride, 2.) 12percent aq. HCl / 1.) reflux, 60 min, 2.) reflux, 4 h 2: 80 percent / 1.) 70percent HClO4, CrO3 / aq. acetic acid / 72 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 213 - 220
反应条件
hydrogenchloride; ammonium hydroxide 1) acetone, reflux, 15 h, 2) H2O; Multistep reaction;
参考文献
Synthetic Communications, , vol. 26, # 12 p. 2305 - 2308
参考文献
Yakugaku Zasshi, , vol. 76, p. 1308
Chem.Abstr., , p. 5076
反应条件
sodium tetrahydroborate
参考文献
SCHERING CORPORATION
Patent: WO2009/45313 A2, 2009 ;
Location in patent: Page/Page column 54 ;
WO 2009/045313 A2
