4-乙基-3,5-二甲基-1H-吡咯-2-甲酸乙酯合成路线 （共 41 条）
反应条件
methanol; Ce(OTf)4; trifluorormethanesulfonic acid; hydrogen bromide 1.) 5 min., r.t. 2.) MeOH, water, 65 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Huggins, Michael T.; Tipton, Adrianne K.; Chen, Qingqi; Lightner, David A.
Monatshefte fur Chemie, 2000 , vol. 131, # 8 p. 825 - 838
反应条件
2,3,7,8,12,13,17,18-octachloro-5,10,15,20-tetra(2',6'-dichlorophenyl)porphyrinatoiron(III) chloride; iodosylbenzene in dichloromethane; trifluoroacetic acid 0.0833333 h;
参考文献
Karunaratne, Veranja; Dolphin, David
Tetrahedron Letters, 1996 , vol. 37, # 5 p. 603 - 604
反应条件
acetic anhydride in acetic acid T=20°C; Acetoxylation; 3 h;
参考文献
Lash, Timothy D.
Tetrahedron, 1998 , vol. 54, # 3-4 p. 359 - 374
反应条件
acetic anhydride; acetic acid T=20°C;
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
反应条件
lead(IV) acetate 2 h;
参考文献
Berezin, M. B.; Semeikin, A. S.; V'yugin, A. I.
Russian Journal of Physical Chemistry, 1996 , vol. 70, # 8 p. 1265 - 1268
Zhurnal Fizicheskoi Khimii, 1996 , vol. 70, # 8 p. 1634 - 1636
反应条件
1: lead (IV)-acetate; acetic acid / Behandeln einer Loesung des Reaktionsprodukts in CHCl3 mit H2O 2: ethanolic KOH View Scheme
参考文献
Siedel; Winkler
Justus Liebigs Annalen der Chemie, 1943 , vol. 554, p. 162,185
反应条件
sulfuryl dichloride; diethyl ether
Erwaermen des Reaktionsprodukts mit wss.-aethanol. HCl;
参考文献
Baciocchi, Enrico; Muraglia, Ester; Sleiter, Giancarlo
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2486 - 2490
反应条件
1: 78 percent / AcOH; Ac2O / 20 °C
2: 81 percent / Montmorillonite clay K-10 / CH2Cl2 / 20 °C
3: NaOH / ethane-1,2-diol / 1 h / Heating
View Scheme
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
反应条件
1: sodium
2: acetic acid
3: Montmorillonite K-10 clay / dichloromethane / 0.5 h / 20 °C
4: diethylamine; palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 20 °C / 760.05 Torr
View Scheme
参考文献
Sabido, Portia Mahal G.; Lightner, David A.
Monatshefte fur Chemie, 2014 , vol. 145, # 5 p. 775 - 789
反应条件
1: 78 percent / AcOH; Ac2O / 20 °C
2: 81 percent / HCl / methanol / 3 h / Heating
3: NaOH / ethane-1,2-diol / 1 h / Heating
View Scheme
参考文献
Lash, Timothy D.
Tetrahedron, 1998 , vol. 54, # 3-4 p. 359 - 374
