1-氨基-1-苯基环己烷合成路线 （共 22 条）
反应条件
sodium dithionite; potassium carbonate; N,N'-dioctyl-4,4'-bipyridinium in water; acetonitrile
T=35°C; 2 h; Yield given. Yields of byproduct given;
参考文献
Park, Kwanghee Koh; Oh, Chang Hun; Sim, Woo-Jeon
Journal of Organic Chemistry, 1995 , vol. 60, # 19 p. 6202 - 6204
反应条件
potassium cyanide; sulfuric acid in anhydrous butyl ether
T=60 - 80°C;
参考文献
Christol,H. et al.
Bulletin de la Societe Chimique de France, 1961 , p. 2319 - 2324
反应条件
(i) aq. NaN3, ClCO2Et, Et3N, acetone, (ii) toluene, (iii) aq. HCl; Multistep reaction;
参考文献
Palmere,R.M.; Conley,R.T.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2703 - 2707
反应条件
(i) NaN3, xylene, (ii) aq. HCl; Multistep reaction;
参考文献
Bonnekessel,J.; Ruechardt,C.
Chemische Berichte, 1973 , vol. 106, p. 2890 - 2903
反应条件
1: tetrahydrofuran / 0.33 h
2: NaN3, CF3COOH / CHCl3 / 1.) 5 deg C, 2.) room temp., overnight
3: LiAlH4 / diethyl ether / 3 h
View Scheme
参考文献
Thurkauf, Andrew; Costa, Brian de; Yamaguchi, Shun-ichi; Mattson, Mariena V.; Jacobson, Arthur E.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1452 - 1458
反应条件
1: aq. KOH / ethane-1,2-diol / Heating
2: SOCl2 / Heating
3: (i) NaN3, toluene, (ii) aq. HCl, toluene
View Scheme
参考文献
Carissimi,M. et al.
Farmaco, Edizione Scientifica, 1966 , vol. 21, p. 155 - 171
反应条件
potassium hydroxide in diethylene glycol
参考文献
Kalir,A.; Pelah,K.
Israel Journal of Chemistry, 1967 , vol. 5, p. 223 - 229
反应条件
1: Br2 / methanol
2: KOH / bis-(2-hydroxy-ethyl) ether
View Scheme
参考文献
Kalir,A.; Pelah,K.
Israel Journal of Chemistry, 1967 , vol. 5, p. 223 - 229
反应条件
1: (i) silver fulminate, I2, Et2O, (ii) aq. HCl
2: LiAlH4 / tetrahydrofuran / Heating
View Scheme
参考文献
Drefahl,G. et al.
Journal fuer Praktische Chemie (Leipzig), 1964 , vol. 23, p. 136 - 142
反应条件
1: KOtBu / 2-methyl-propan-2-ol
2: KOH / bis-(2-hydroxy-ethyl) ether
3: SOCl2 / dimethylformamide
4: (i) NaN3, xylene, (ii) aq. HCl
View Scheme
参考文献
Bonnekessel,J.; Ruechardt,C.
Chemische Berichte, 1973 , vol. 106, p. 2890 - 2903
