反应条件
1: 1.) Mg, I2 / 1.) anhydrous THF, 4 h, 60 deg C, 2.) THF 2: 97 percent / H2O, 10percent HCl / methanol / 1 h / Ambient temperature 3: 1.) t-BuOK / 1.) anhydrous THF, 30 min, RT, 2.) THF, RT, 24 h 4: 58 percent / LAH / diethyl ether / 6 h / -78 °C 5: 93 percent / m-CPBA (80 percent) / CH2Cl2 / 0.67 h / 0 °C 6: 97 percent / H2, 1M NaOH / 10percent Pd/C / ethanol / 6 h / -60 °C 7: 89 percent / LiBr, NCS / methanol / 1 h / Ambient temperature 8: 79 percent / TsOH / 5 h / Ambient temperature 9: 1.) t-BuLi / 1.) Et2O, hexane, -78 deg C, 1.75 h, 2.) Et2O, hexane, RT 10: 93 percent / H2O, 5percent HCl / methanol / RT, 8 h, then -20 deg C, 16 h 11: 72 percent / RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 1.25 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 51, # 46 p. 12645 - 12660
