4-羟基-2,6-二甲氧基苯甲醛合成路线 （共 19 条）
反应条件
Kochen des Reaktionsprodukts mit Wasser;
参考文献
Chemische Berichte, , vol. 76, p. 135,139
反应条件
1: 1.) KOtBu / 1.) DMF, 25 deg C, 2.) 110 deg C, 5h 2: 4N aq. NaOH / methanol / 1 h / 25 °C 3: 95 percent / NH2OH, Na2CO3 / H2O / 2 h 4: 96 percent / H2 / 10percent Pd/C / aq. acetic acid / 2 h / 25 °C / 2280 Torr View Scheme
参考文献
Albericio; Kneib-Cordonier; Biancalana; Gera; Masada; Hudson; Barany
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3730 - 3743
反应条件
1: 1.) KOtBu / 1.) DMF, 25 deg C, 2.) 110 deg C, 5h 2: 4N aq. NaOH / methanol / 1 h / 25 °C 3: 95 percent / NH2OH, Na2CO3 / H2O / 2 h 4: 96 percent / H2 / 10percent Pd/C / aq. acetic acid / 2 h / 25 °C / 2280 Torr 5: aq. Na2CO3 / dioxane / 3 h / 25 °C View Scheme
参考文献
Albericio; Kneib-Cordonier; Biancalana; Gera; Masada; Hudson; Barany
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3730 - 3743
反应条件
potassium tert-butylate 1.) DMF, 25 deg C, 2.) 110 deg C, 5h; Yield given. Multistep reaction;
参考文献
Albericio; Kneib-Cordonier; Biancalana; Gera; Masada; Hudson; Barany
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3730 - 3743
反应条件
1: 1.) KOtBu / 1.) DMF, 25 deg C, 2.) 110 deg C, 5h 2: 4N aq. NaOH / methanol / 1 h / 25 °C View Scheme
参考文献
Albericio; Kneib-Cordonier; Biancalana; Gera; Masada; Hudson; Barany
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3730 - 3743
反应条件
potassium carbonate in acetone
14 h; Reflux;
参考文献
Lang; Ma; Kim; Jagoda; Rice; Szajek; Contoreggi; Gold; Chrousos; Eckelman; Kiesewettera
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 394 - 400
反应条件
tributylphosphine; 1,1'-azodicarbonyl-dipiperidine in tetrahydrofuran
T=20°C; 18 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1559422 A1, 2005 ;
Location in patent: Page/Page column 130; 131 ;
EP 1559422 A1
反应条件
potassium carbonate in acetone
参考文献
Lang; Ma; Kim; Jagoda; Rice; Szajek; Contoreggi; Gold; Chrousos; Eckelman; Kiesewettera
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 394 - 400
反应条件
1: ethanol; aqueous HCl; amalgamated zinc
2: hydrogen cyanide; diethyl ether; HCl / und Erwaermen des Reaktionsprodukts mit Wasser
View Scheme
参考文献
Gruber
Chemische Berichte, 1943 , vol. 76, p. 135,139
