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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-氰基溴苄
合成路线
（共 67 条）
7647-01-0
盐酸
+
22115-41-9
2-氰基溴苄
→
反应条件
87-41-2
苯酞
反应条件
Hydrolysis;
参考文献
Fuson
Journal of the American Chemical Society, 1926 , vol. 48, p. 834
108-94-1
环己酮
+
22115-41-9
2-氰基溴苄
→
反应条件
2674-47-7
反应条件
Yield given. Multistep reaction;
参考文献
Kanda; Kato; Sugino; Kambe; Ogawa; Sonoda
Synthesis, 1995 , # 9 p. 1102 - 1106
22115-41-9
2-氰基溴苄
+
122-52-1
亚磷酸三乙酯
→
反应条件
23973-65-1
反应条件
T=150°C; Arbuzov reaction; 20 h;
参考文献
Imamura, Shinichi; Ichikawa, Takashi; Nishikawa, Youichi; Kanzaki, Naoyuki; Takashima, Katsunori; Niwa, Shinichi; Iizawa, Yuji; Baba, Masanori; Sugihara, Yoshihiro
Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2784 - 2793
4318-56-3
6-氯-3-甲基尿嘧啶
+
22115-41-9
2-氰基溴苄
→
反应条件
865758-96-9
2-[(6-氯-3,4-二氢-3-甲基-2,4-二氧代-1（2H）-嘧啶）甲基]丁苯甲腈
反应条件
N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=0 - 70°C; Inert atmosphere;
参考文献
Takeda Pharmaceutical Company Limited; HARADA, Kazuki; FUKUYAMA, Hikaru; KOIKE, Masahiko
Patent: EP2682110 A1, 2014 ;
Location in patent: Paragraph 0109-0112 ;
22115-41-9
2-氰基溴苄
→
反应条件
865758-96-9
2-[(6-氯-3,4-二氢-3-甲基-2,4-二氧代-1（2H）-嘧啶）甲基]丁苯甲腈
反应条件
1.1: NaH / dimethylformamide; dimethylsulfoxide / 0.5 h / 0 °C 1.2: LiBr / dimethylformamide; 1,2-dimethoxy-ethane / 0.25 h / 0 - 20 °C 1.3: 54 percent / dimethylformamide; dimethylsulfoxide / 0 - 20 °C 2.1: NaH; LiBr / dimethylformamide; tetrahydrofuran / 0.33 h / 20 °C 2.2: 72 percent / dimethylformamide; tetrahydrofuran / 0 - 35 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MOHANBABU, Maradolla; VAMSI KRISHNA, Bandi
Patent: WO2013/46229 A1, 2013 ;
22115-41-9
2-氰基溴苄
→
反应条件
216312-53-7
N-叔丁氧羰基-L-2-氰基苯丙氨酸
反应条件
1: Bu4N(HSO4); NaOH / CH2Cl2; H2O / 24 h / 20 °C 2: 85 percent / HCl / acetone; H2O / 3 h / 20 °C 3: 88 percent / Et3N / CH2Cl2 / 1 h / 20 °C 4: α-chymotrypsin / H2O / 37 °C / pH 5 5: 81 percent / HCl / H2O / 4 h / Heating 6: NaOH / dioxane; ethyl acetate / 20 °C / pH 8 View Scheme
参考文献
Van Rompaey, Karolien; Van Den Eynde, Isabelle; De Kimpe, Norbert; Tourwe, Dirk
Tetrahedron, 2003 , vol. 59, # 24 p. 4421 - 4432
22115-41-9
2-氰基溴苄
→
反应条件
850649-61-5
阿格列汀
反应条件
1.1: NaH / dimethylformamide; dimethylsulfoxide / 0.5 h / 0 °C 1.2: LiBr / dimethylformamide; 1,2-dimethoxy-ethane / 0.25 h / 0 - 20 °C 1.3: 54 percent / dimethylformamide; dimethylsulfoxide / 0 - 20 °C 2.1: NaH; LiBr / dimethylformamide; tetrahydrofuran / 0.33 h / 20 °C 2.2: 72 percent / dimethylformamide; tetrahydrofuran / 0 - 35 °C 3.1: 2.7 g / NaHCO3; molecular sieves 4 Angstroem / ethanol / 4 h / 100 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MOHANBABU, Maradolla; VAMSI KRISHNA, Bandi
Patent: WO2013/46229 A1, 2013 ;
22115-41-9
2-氰基溴苄
→
反应条件
288252-67-5
反应条件
sulfuric acid; nitric acid T=20°C; 18 h;
参考文献
Oshima, Juro; Tsujimoto, Hitomi; Yoshihara, Toshitada; Yamada, Keiichi; Katakai, Ryoichi; Tobita, Seiji
Chemistry Letters, 2006 , vol. 35, # 6 p. 620 - 621
4270-27-3
+
22115-41-9
2-氰基溴苄
→
反应条件
865758-95-8
反应条件
1: 6-chloropyrimidine-2,4-dione With sodium hydride in dimethyl sulfoxide; N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 2: With lithium bromide in dimethyl sulfoxide; N,N-dimethyl-formamide T=0°C; 0.25 h; Inert atmosphere; 3: 2-bromomethyl-benzonitrile in dimethyl sulfoxide; N,N-dimethyl-formamide T=0 - 20°C; 13 h; Inert atmosphere;
参考文献
Kodimuthali, Arumugam; Pal, Manojit; Prasunamba, Padala Lakshmi
Beilstein Journal of Organic Chemistry, 2010 , vol. 6, art. no. 71
22115-41-9
2-氰基溴苄
→
反应条件
865758-95-8
反应条件
1: 6-chloropyrimidine-2,4-dione With sodium hydride in DMF (N,N-dimethyl-formamide); dimethyl sulfoxide T=0°C; 0.5 h; 2: With lithium bromide in DMF (N,N-dimethyl-formamide); dimethyl sulfoxide T=0°C; 0.25 h; 3: 2-bromomethyl-benzonitrile in DMF (N,N-dimethyl-formamide); dimethyl sulfoxide T=0 - 20°C;
参考文献
Andres, Mark; Lorimer, Keith
Patent: US2007/66635 A1, 2007 ;
Location in patent: Page/Page column 13; 14 ;
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