4-苄氧基-3-甲氧基苯乙胺合成路线 （共 39 条）
反应条件
T=15 - 20°C; Electrolysis;
参考文献
Yakugaku Zasshi, , vol. 58, p. 783,486;dtsch.Ref.S.223,226
Chem. Zentralbl., , vol. 110, # I p. 1978
反应条件
palladium on charcoal in tetrahydrofuran
参考文献
Grammenos, Wassilios; Sauter, Hubert; Cullmann, Oliver; Gewehr, Markus; Muller, Bernd; Blasco, Jordi Tormo i; Gotz, Norbert; Volk, Thorsten; Lorenz, Gisela; Ammermann, Eberhard; Stierl, Reinhard; Strathman, Siegfried
Patent: US2003/191190 A1, 2003 ;
反应条件
hydrogenchloride in diethyl ether
参考文献
UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
Patent: WO2008/69632 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
1: ethanol / 14 h / |Reflux 2: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 3: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 4: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 5: water; sodium hydroxide / ethanol / 3 h / 20 °C 6: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 7: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 8: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1.1: triethylamine / dichloromethane / 3 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 3.1: sodium hydroxide / chloroform / 0 - 20 °C 4.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere 4.2: 20 °C / Inert atmosphere; Cooling with ice 5.1: palladium 10 on activated carbon; hydrogen; acetic acid / methanol / 16 h 6.1: berberine bridge enzyme; tris(hydroxymethyl)methylamine hydrochloride; magnesium chloride / toluene / 24 h / 40 °C / pH 9 / Darkness; Enzymatic reaction View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
1: NaHCO3 / methanol 2: aq. KOH / ethanol / Heating View Scheme
参考文献
Kametani,T. et al.
Tetrahedron, 1975 , vol. 31, p. 235 - 238
反应条件
triethylamine in dichloromethane
参考文献
MILLER, James Jackson; PHILLIPS, Anthony George; LAPISH, Christopher Court; SAMMIS, Glenn Martin
Patent: WO2013/20229 A1, 2013 ;
Location in patent: Paragraph 0189 ;
WO 2013/020229 A1
反应条件
T=180°C; Neat (no solvent);
参考文献
MILLER, James Jackson; PHILLIPS, Anthony George; LAPISH, Christopher Court; SAMMIS, Glenn Martin
Patent: WO2013/20229 A1, 2013 ;
Location in patent: Paragraph 0183 ;
WO 2013/020229 A1
反应条件
ethanol; water und Erwaermen des Reaktionsprodukts mit wss. Salzsaeure;
参考文献
Onda et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 409,410, 411
Chem. Zentralbl., 1956 , vol. 127, p. 13930
反应条件
1: formic acid / 48 h / 50 °C 2: 88 percent / ammonium sulfate / toluene / 48 h / Heating 3: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 4: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 5: K2CO3 / acetone / 14 h / Heating 6: lithium aluminum hydride / tetrahydrofuran / Heating 7: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme
参考文献
Meyers, A. I.; Guiles, Joseph
Heterocycles, 1989 , vol. 28, # 1 p. 295 - 301
