3,4-二氢-7-羟基-2(1H)-喹啉酮合成路线 （共 27 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 627, p. 224,225
反应条件
1: Raney nickel; ethanol / Hydrogenation 2: aqueous hydrobromic acid View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 627, p. 224,225
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Inert atmosphereCooling with iceReflux;
参考文献
Anzalone, Andrew V.; Wang, Tracy Y.; Chen, Zhixing; Cornish, Virginia W.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 2 p. 650 - 654
Angew. Chem., 2013 , vol. 125, # 2 p. 678 - 682,5
反应条件
in DMF (N,N-dimethyl-formamide); isobutyl methylketone 18 h; Heating / reflux;
参考文献
DELMAR CHEMICALS INC.
Patent: WO2004/99152 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
1: 78 percent / K2CO3 / dimethylformamide / 4 h / 60 °C 2: 1.) NaI, 2.) Et3N / 1.) CH3CN, reflux, 30 min, 2.) CH3CN, reflux, 4 h View Scheme
参考文献
Kowalski, Piotr; Jaskowska, Jolanta
Archiv der Pharmazie, 2012 , vol. 345, # 1 p. 81 - 85
反应条件
1: 7-Hydroxy-3,4-dihydro-1H-quinolin-2-one With potassium carbonate in water; acetone T=20°C; 1 h; 2: 1,4-dibromo-butane in water; acetone T=20°C; 16 h;
参考文献
Asian Journal of Chemistry, , vol. 23, # 4 p. 1655 - 1660
反应条件
sodium hydroxide in isobutyramide T=36 - 40°C; 4 h; Product distribution / selectivity;
参考文献
US2006/258869 A1, ;
Page/Page column 3-5 ;
反应条件
potassium carbonate; tetrabutylammomium bromide in water T=90°C; 2 - 3 h; Product distribution / selectivity;
参考文献
WO2007/118923 A1, ;
Page/Page column 7-8 ;
反应条件
potassium carbonate; polyethylene glycol-400 in water; acetone T=20°C; 15.1667 - 16.1667 h;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2007/94009 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium carbonate in propan-1-ol 8 - 10 h; Heating / reflux; Product distribution / selectivity;
参考文献
Naddaka, Vladimir; Brand, Michael; Davidi, Guy; Klopfer, Eyal; Gribun, Irina; Arad, Oded; Kaspi, Joseph
Patent: US2006/79689 A1, 2006 ;
Location in patent: Page/Page column 9; 10 ;
