1: 80 percent / aq. NaOH; H2 / Raney Ni / 1 h / 150 °C / 68400 - 76000 Torr 2: aq. DIEA / dioxane / 3 h / 20 °C View Scheme

N-ethyl-N,N-diisopropylamine in 1,4-dioxane T=20°C; 3 h;

1: lipase PS Amano; phosphate buffer / 20 °C / pH 7.2 2: diphenylphosphoryl azide; triethylamine / toluene / 95 °C 3: aq. NaOH / tetrahydrofuran / 50 °C View Scheme

1: diphenylphosphoryl azide; triethylamine / toluene / 95 °C 2: aq. NaOH / tetrahydrofuran / 50 °C View Scheme

1.1: sodium hydroxide; hydrogen / water / 12 h / 150 °C / 68404.6 - 76005.1 Torr 1.2: pH 2 2.1: N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 3 h / 20 °C 2.2: pH 2 / |Acidic conditions 3.1: (R)-1-phenyl-ethyl-amine / hexane; chloroform / |Resolution of racemate View Scheme