您好，欢迎来到魔法化学网！
合作交流
|
服务时间(9:30-18:00)
百科
百科
▼
百科
资讯
搜索
结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
首页
化合物百科
价格行情
资讯
化工导航
实验室工具
搜索
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
222835-03-2
合成路线
（共 13 条）
4397-53-9
4-苄氧基苯甲醛
+
13676-06-7
2-乙氧基三乙基磷酸乙酯
→
反应条件
222835-03-2
反应条件
potassium tert-butylate in tert-butyl alcohol T=15°C; Horner-Emmons-Wadsworth reaction; 0.5 h;
参考文献
Shen, Jianhua; Mei, Changlin; Jiang, Hualiang; Dai, Bin; Ye, Yangliang; Xiong, Xishan; Tang, Jing; Fu, Lili
Patent: US2010/240636 A1, 2010 ;
Location in patent: Page/Page column 12 ;
4397-53-9
4-苄氧基苯甲醛
→
反应条件
222835-03-2
反应条件
potassium tert-butylate; triethyl phosphite in tert-butyl methyl ether; tert-butyl alcohol T=5 - 15°C; 0.5 h;
参考文献
SHANGHAI INSTITUTE OF MATERIA MEDICA, CAS; CHANGZHEN HOSPITAL, SHANGHAI
Patent: WO2009/46606 A1, 2009 ;
Location in patent: Page/Page column 17 ;
WO 2009/046606 A1
4397-53-9
4-苄氧基苯甲醛
+
16847-90-8
(1,2-二乙氧基-2-氧代乙基)(三苯基)鏻氯化物
→
反应条件
222835-03-2
反应条件
TMG in dichloromethane T=0 - 20°C; Wittig olefination;
参考文献
Kim, Nam-Jung; Lee, Kwang-Ok; Koo, Bon-Woong; Li, Funan; Yoo, Ja-Kyung; Park, Hyun-Ju; Min, Kyung-Hoon; Lim, Joong In; Kim, Mi Kyung; Kim, Jin-Kwan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3595 - 3598
361576-28-5
→
反应条件
222835-03-2
反应条件
暂无反应条件数据
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/789 A1, 2003 ;
Location in patent: Page 28 ;
WO 2004/000789 A1
100-44-7
苄基氯
→
反应条件
222835-03-2
反应条件
1: 93 percent / K2CO3 / dimethylformamide / 80 °C 2: 93 percent / tetramethylguanidine / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Kim, Nam-Jung; Lee, Kwang-Ok; Koo, Bon-Woong; Li, Funan; Yoo, Ja-Kyung; Park, Hyun-Ju; Min, Kyung-Hoon; Lim, Joong In; Kim, Mi Kyung; Kim, Jin-Kwan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3595 - 3598
123-08-0
对羟基苯甲醛
→
反应条件
222835-03-2
反应条件
1: 93 percent / K2CO3 / dimethylformamide / 80 °C 2: 93 percent / tetramethylguanidine / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Kim, Nam-Jung; Lee, Kwang-Ok; Koo, Bon-Woong; Li, Funan; Yoo, Ja-Kyung; Park, Hyun-Ju; Min, Kyung-Hoon; Lim, Joong In; Kim, Mi Kyung; Kim, Jin-Kwan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3595 - 3598
6065-82-3
2,2-二乙氧基乙酸乙酯
→
反应条件
222835-03-2
反应条件
1: acetyl chloride; iodine 2: 150 °C 3: potassium tert-butylate / toluene View Scheme
参考文献
Deussen, Heinz-Josef; Zundel, Magali; Valdois, Marine; Lehmann, Soren Vig; Weil, Volker; Mailand Hjort, Carsten; stergaard, Peter Rahbek; Marcussen, Erik; Ebdrup, Soren
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 82 - 88
34006-60-5
2-氯-2-乙氧基乙酸乙脂
→
反应条件
222835-03-2
反应条件
1: 150 °C 2: potassium tert-butylate / toluene View Scheme
参考文献
Deussen, Heinz-Josef; Zundel, Magali; Valdois, Marine; Lehmann, Soren Vig; Weil, Volker; Mailand Hjort, Carsten; stergaard, Peter Rahbek; Marcussen, Erik; Ebdrup, Soren
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 82 - 88
222835-03-2
→
反应条件
325793-65-5
(S)-2-乙氧基-3-(4-羟基苯基)-丙酸
反应条件
1: 99 percent / H2 / 5 percent Pd/C / various solvent(s) / 20 °C / atmospheric pressure 2: 39 percent / Pectinex Ultra SP-L enzyme; aq. phosphate buffer / 44 h / 20 °C / pH 7.0 View Scheme
参考文献
Ebdrup, Soren; Pettersson, Ingrid; Rasmussen, Hanne B.; Deussen, Heinz-Josef; Jensen, Anette Frost; Mortensen, Steen B.; Fleckner, Jan; Pridal, Lone; Nygaard, Lars; Sauerberg, Per
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1306 - 1317
222835-03-2
→
反应条件
222555-05-7
+
325793-65-5
(S)-2-乙氧基-3-(4-羟基苯基)-丙酸
反应条件
1: hydrogen; acetic acid / ethanol / 1500.15 - 4500.45 Torr 2: Aspergillus oryzae hydrolytic enzyme mixture / aq. phosphate buffer / 16 h / 20 °C / pH 7 / |Resolution of racemate; |Large scale; |Enzymatic reaction View Scheme
参考文献
Deussen, Heinz-Josef; Zundel, Magali; Valdois, Marine; Lehmann, Soren Vig; Weil, Volker; Mailand Hjort, Carsten; stergaard, Peter Rahbek; Marcussen, Erik; Ebdrup, Soren
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 82 - 88
1
2
下一页
末页
到第
页
确定
