alpha-(2-甲基丙亚基)吡啶-2-乙腈合成路线 （共 6 条）
反应条件
piperidine; acetic acid in benzene 3 h; Heating;
参考文献
Bernhart; Condamine; Demarne; Roncucci; Gagnol; Gautier; Serre
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 451 - 455
反应条件
acetic acid in benzene
参考文献
C.M. Industries
Patent: US4356177 A1, 1982 ;
反应条件
sodium hydride; tetrakis(triphenylphosphine) palladium(0) 1.) DME; 2.) DMF, 15 h; Yield given. Multistep reaction;
参考文献
Sakamoto; Katoh; Kondo; Yamanaka
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 6 p. 1513 - 1517
反应条件
1: 99 percent / H2 / 5 percent Pd/C / ethanol / 760 Torr / Ambient temperature
2: sodamide / toluene / 2 h / Heating
3: 54 percent / conc. H2SO4 / 1 h / 120 °C
View Scheme
参考文献
Bernhart; Condamine; Demarne; Roncucci; Gagnol; Gautier; Serre
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 451 - 455
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=760 Torr; Ambient temperature;
参考文献
Bernhart; Condamine; Demarne; Roncucci; Gagnol; Gautier; Serre
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 451 - 455
反应条件
1: 99 percent / H2 / 5 percent Pd/C / ethanol / 760 Torr / Ambient temperature
2: sodamide / toluene / 2 h / Heating
View Scheme
参考文献
Bernhart; Condamine; Demarne; Roncucci; Gagnol; Gautier; Serre
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 451 - 455
