1-甲基-4-(3-吡啶基)哌嗪合成路线 （共 5 条）
反应条件
CpPd(SIPr)Cl; sodium t-butanolate in ethylene glycol dimethyl ether T=23°C; Buchwald-Hartwig reaction; 12 h; Inert atmosphere;
参考文献
Chartoire, Anthony; Frogneux, Xavier; Nolan, Steven P.
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 1897 - 1901
反应条件
C22H26Cl2NPPd; sodium t-butanolate in toluene T=110°C; 22 h; Inert atmosphere;
参考文献
Samblanet, Danielle C.; Schmidt, Joseph A. R.
Journal of Organometallic Chemistry, 2012 , vol. 720, p. 7 - 18,12
反应条件
formic acid in ethanol; water 3 h; Heating;
参考文献
Manetti, Dina; Bartolini, Alessandro; Borea, Pier Andrea; Bellucci, Cristina; Dei, Silvia; Ghelardini, Carla; Gualtieri, Fulvio; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 457 - 465
反应条件
1: 35 percent / CuSO4 / H2O / 24 h / 140 °C 2: 68 percent / ammonium formiate / 10 percent Pd/C / methanol / 3 h / Heating 3: 46 percent / formic acid / ethanol; H2O / 3 h / Heating View Scheme
参考文献
Manetti, Dina; Bartolini, Alessandro; Borea, Pier Andrea; Bellucci, Cristina; Dei, Silvia; Ghelardini, Carla; Gualtieri, Fulvio; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 457 - 465
反应条件
1: 68 percent / ammonium formiate / 10 percent Pd/C / methanol / 3 h / Heating 2: 46 percent / formic acid / ethanol; H2O / 3 h / Heating View Scheme
参考文献
Manetti, Dina; Bartolini, Alessandro; Borea, Pier Andrea; Bellucci, Cristina; Dei, Silvia; Ghelardini, Carla; Gualtieri, Fulvio; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 457 - 465
