1-(6-溴-3-吡啶)高哌嗪合成路线 （共 4 条）
反应条件
N-bromosuccinmide in acetonitrile Bromination; 0.25 h;
参考文献
Neurosearch A/S
Patent: US2004/72823 A1, 2004 ;
Location in patent: Page/Page column 21 ;
反应条件
1: 13 percent / tetrakis(triphenylphosphine)palladium(0); potassium tert-butoxide / toluene / 4 h / 80 °C 2: 85 percent / trifluoroacetic acid / CH2Cl2 / 6 h 3: 39 percent / N-bromosuccinimide / acetonitrile / 0.25 h View Scheme
参考文献
Nielsen, Simon Feldbk; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Liljefors, Tommy; Peters, Dan
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2217 - 2226
反应条件
1: 13 percent / tetrakis(triphenylphosphine)palladium(0); potassium tert-butoxide / toluene / 4 h / 80 °C 2: 85 percent / trifluoroacetic acid / CH2Cl2 / 6 h 3: 39 percent / N-bromosuccinimide / acetonitrile / 0.25 h View Scheme
参考文献
Nielsen, Simon Feldbk; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Liljefors, Tommy; Peters, Dan
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2217 - 2226
反应条件
1: 85 percent / trifluoroacetic acid / CH2Cl2 / 6 h 2: 39 percent / N-bromosuccinimide / acetonitrile / 0.25 h View Scheme
参考文献
Nielsen, Simon Feldbk; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Liljefors, Tommy; Peters, Dan
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2217 - 2226
