4-(3-吡啶)-1-哌嗪羧酸-1,1-二甲基乙酯合成路线 （共 4 条）
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene T=85°C;
参考文献
AMGEN INC.
Patent: WO2009/85185 A1, 2009 ;
Location in patent: Page/Page column 114-115 ;
WO 2009/085185 A1
反应条件
sodium hydrogencarbonate in dichloromethane T=20°C;
参考文献
Audouze, Karine; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Ahring, Philip; Jorgensen, Tino Dyhring; Peters, Dan; Liljefors, Tommy; Balle, Thomas
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3159 - 3171
反应条件
trifluoroacetic acid in dichloromethane 15 h;
参考文献
Neurosearch A/S
Patent: US2004/72823 A1, 2004 ;
Location in patent: Page/Page column 14 ;
反应条件
N-bromosuccinmide in acetonitrile
T=20°C; 1 h;
参考文献
Audouze, Karine; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Ahring, Philip; Jorgensen, Tino Dyhring; Peters, Dan; Liljefors, Tommy; Balle, Thomas
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3159 - 3171
