2-(4-溴苯基)-1-苯基乙酮合成路线 （共 15 条）
反应条件
1: 4-bromo-benzyl bromide With manganese in tetrahydrofuran T=20°C; Metallation; 0.333333 h; 2: benzoyl chloride in tetrahydrofuran T=20°C; Substitution; 2 h;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2322 - 2330
反应条件
oxygen; pivalaldehyde; Co(III) ortho-phenylene-bis(N'-methyloxamidate) in acetonitrile T=20°C;
参考文献
Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Pedro, Jose R.
Molecules, 2004 , vol. 9, # 5 p. 365 - 372
反应条件
1: 4-bromobenzyl methanesulfonate With manganese in tetrahydrofuran T=20°C; Metallation; 0.5 h; 2: benzoyl chloride in tetrahydrofuran; ethylene dibromide T=20°C; Addition; 0.5 h;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2322 - 2330
反应条件
tri-ruthenium(0)dodecacarbonyl in toluene T=120°C; 40 h;
参考文献
Tatamidani, Hiroto; Yokota, Kazuhiko; Kakiuchi, Fumitoshi; Chatani, Naoto
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5615 - 5621
反应条件
AlCl3, aluminium chloride T=20°C; 1 - 1.5 h;
参考文献
THE DOW CHEMICAL COMPANY
Patent: EP1170279 A1, 2002 ;
Location in patent: Example 1A(b) ;
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene] dichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=100°C; Stille coupling; 16 h;
参考文献
Saevmarker, Jonas; Lindh, Jonas; Nilsson, Peter
Tetrahedron Letters, 2010 , vol. 51, # 52 p. 6886 - 6889
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene] dichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=100°C; Stille coupling; 16 h;
参考文献
Saevmarker, Jonas; Lindh, Jonas; Nilsson, Peter
Tetrahedron Letters, 2010 , vol. 51, # 52 p. 6886 - 6889
反应条件
1: 2-(4-bromophenyl)acetic acid With thionyl chloride 3 h; Heating; 2: benzene With aluminium trichloride in dichloromethane 2 h; Heating; Further stages.;
参考文献
Kuo, Wen-Jang; Chen, Ying-Hsiao; Jeng, Ru-Jong; Chan, Li-Hsin; Lin, Wen-Peng; Yang, Zhe-Ming
Tetrahedron, 2007 , vol. 63, # 30 p. 7086 - 7096
反应条件
1.1: 65 percent / H2SO4 / toluene / 24 h / 20 °C 2.1: n-BuLi; iPr2NH / hexane; tetrahydrofuran / 0.5 h / -78 °C 2.2: 75 percent / hexane; tetrahydrofuran / 4 h / -78 - 20 °C 3.1: 100 percent / KOH / ethanol / 3 h / 20 °C 4.1: 94 percent / pivalaldehyde; O2 / Co(III)-Me2opba / acetonitrile / 20 °C View Scheme
参考文献
Molecules, , vol. 9, # 5 p. 365 - 372
反应条件
1.1: n-BuLi; iPr2NH / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: 75 percent / hexane; tetrahydrofuran / 4 h / -78 - 20 °C 2.1: 100 percent / KOH / ethanol / 3 h / 20 °C 3.1: 94 percent / pivalaldehyde; O2 / Co(III)-Me2opba / acetonitrile / 20 °C View Scheme
参考文献
Molecules, , vol. 9, # 5 p. 365 - 372
