N,N,N',N,-tetramethylethylenediamine; Co(acac)3 in tetrahydrofuran T=0°C; 0.666667 h; Inert atmosphere; chemoselective reaction;

indium trifluoromethanesulfonate in dichloromethane T=0 - 20°C; 2.16667 h;

copper(I) oxide; copper diacetate; acetic acid in acetonitrile

T=90°C; 72 h; Title compound not separated from byproducts;

1: 85 percent / indium triflate (In(OTf)3) / CH2Cl2 / 0.5 h / 0 °C 2: 90 percent / indium triflate (In(OTf)3) / CH2Cl2 / 2.17 h / 0 - 20 °C View Scheme

in acetonitrile addn. of 5.0 equiv. of trimethylsilyl cyanide to a stirred soln. of the Fe-salt in acetonitrile; storing at room temperature for 16 h; pouring into water;; extraction with ethyl acetate; washing with brine and water; drying the organic layer with Na2SO4; evaporation under reduced pressure; radial chromy., hexane/ethyl acetate (5:1) as eluent;;

T=80°C; 150 h;

(i) LiAlH4, (ii) /BRN= 605303/; Multistep reaction;

1: LiAlH4 2: POCl3 3: 50 percent / 150 h / 80 °C View Scheme

zinc