4-氨基-3,5-二溴苯乙酮合成路线 （共 8 条）
反应条件
N-bromosuccinmide; lithium perchlorate; silica gel in dichloromethane T=20°C; 5 h;
参考文献
Bagheri, Mojtaba; Azizi, Najmedin; Saidi, Mohammad R.
Canadian Journal of Chemistry, 2005 , vol. 83, # 2 p. 146 - 149
反应条件
1: With Trimethylphenylammonium tribromide in tetrahydrofuran T=0°C; 2: With hydrogenchloride in tetrahydrofuran 1 h; Further stages.;
参考文献
Nery, Marcelo S.; Azevedo, Mariangela S.; Cardoso, Jari N.; Slana, Glaucia B. C.; Lopes, Rosangela S. C.; Lopes, Claudio C.
Synthesis, 2007 , # 10 p. 1471 - 1474
参考文献
Fuchs
Monatshefte fuer Chemie, 1915 , vol. 36, p. 132
反应条件
1: NaNO2, conc. H2SO4 / acetic acid / below 20 deg C, then 1 h, 30 deg C 2: CuBr, 36percent HBr / acetic acid / ice-water cooling, then 80 deg C View Scheme
参考文献
Tashiro, Masashi; Mataka, Shuntaro; Nakamura, Hiroshi; Nakayama, Kouji
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 179 - 182
参考文献
Elion
Recueil des Travaux Chimiques des Pays-Bas, 1923 , vol. 42, p. 151,153,164,168
Recueil des Travaux Chimiques des Pays-Bas, 1924 , vol. 43, p. 867
反应条件
1: With sulfuric acid in ethanol; benzene T=50°C; 0.75 h; 2: With copper; sodium nitrite in ethanol; water; benzene T=10°C; 15 h; Reflux;
参考文献
Lintnerova, Lucia; Garcia-Caballero, Melissa; Gregan, Fridrich; Melichercik, Milan; Quesada, Ana R.; Dobias, Juraj; Lac, Jan; Salisova, Marta; Bohac, Andrej
European Journal of Medicinal Chemistry, 2014 , vol. 72, p. 146 - 159
反应条件
Erwaermen des Diazoniumsalzes mit Kupfersulfat und verd. Alkohol.Diazotization;
参考文献
Fuchs
Monatshefte fuer Chemie, 1915 , vol. 36, p. 132
反应条件
1: conc. H2SO4, NaNO2, Cu powder / benzene; ethanol / 50 deg C, then reflux, 3 h and below 10 deg C, then reflux, 3 h
2: 1.) 5 percent NaOD-D2O, Cu-Al alloy, 2.) KMnO4 / 1.) addition gradually, 50 deg C, 140 min
View Scheme
参考文献
Tashiro, Masashi; Mataka, Shuntaro; Nakamura, Hiroshi; Nakayama, Kouji
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 179 - 182
