5-溴-2-甲基-2-戊烯合成路线 （共 93 条）
反应条件
2: 1.) KOH 2.) LiAlH4
View Scheme
参考文献
Mori, Kenji; Sugai, Takeshi; Maeda, Yukari; Okazaki, Tomomi; Noguchi, Tadashi; Naito, Hiroshi
Tetrahedron, 1985 , vol. 41, # 22 p. 5307 - 5312
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 1633817/
2: aq. HBr / 0.5 h / 10 - 15 °C
3: (i) Mg, Et2O, (ii) /BRN= 1633817/, Et2O
4: aq. HBr / 0.75 h / Ambient temperature
5: KOH
View Scheme
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 1072 - 1079
反应条件
n-butyllithium
1.) THF, -72 deg C, 2.) 48 h; Yield given. Further byproducts given. Title compound not separated from byproducts;
参考文献
Elvidge, John A.; Jones, Stephen P.; Peppard, Terence L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1089 - 1094
反应条件
n-butyllithium
1.) ether, -72 deg C, 2.) 48 h;
参考文献
Elvidge, John A.; Jones, Stephen P.; Peppard, Terence L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1089 - 1094
反应条件
n-butyllithium
1.) THF, -72 deg C, 2.) 48 h; Yield given. Further byproducts given. Title compound not separated from byproducts;
参考文献
Elvidge, John A.; Jones, Stephen P.; Peppard, Terence L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1089 - 1094
反应条件
n-butyllithium
1.) ether, -72 deg C, 2.) 48 h;
参考文献
Elvidge, John A.; Jones, Stephen P.; Peppard, Terence L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1089 - 1094
反应条件
2: 1.) KOH 2.) LiAlH4
4: NaI
View Scheme
参考文献
Mori, Kenji; Sugai, Takeshi; Maeda, Yukari; Okazaki, Tomomi; Noguchi, Tadashi; Naito, Hiroshi
Tetrahedron, 1985 , vol. 41, # 22 p. 5307 - 5312
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diethylamide
参考文献
Takeda, Kei; Sato, Masa-aki; Yoshii, Eiichi
Tetrahedron Letters, 1986 , vol. 27, # 33 p. 3903 - 3906
反应条件
1: 5-Bromo-2-methyl-pent-2-ene With magnesium in diethyl ether
T=20°C;
2: 3-ethoxy-2-cyclohexen-1-one in tetrahydrofuran; diethyl ether
T=0 - 20°C;
参考文献
Palais, Laetitia; Alexakis, Alexandre
Chemistry - A European Journal, 2009 , vol. 15, # 40 p. 10473 - 10485
反应条件
tert.-butyl lithium
1) ether, pentane, -23 deg C, 2 h; 2) ether, pentane, -78 deg C, 50 min; Multistep reaction. Yields of byproduct given;
参考文献
Coates, Robert M.; Jin, Alan Qingwu
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7475 - 7478
