3,4,5,6-四甲基吡嗪合成路线 （共 23 条）
反应条件
(NH4)2S2O8; silver nitrate in sulfuric acid
T=90°C; 1 h; Further byproducts given;
参考文献
Heinisch, Gottfried; Loutsch, Gerhard
Heterocycles, 1984 , vol. 22, # 6 p. 1395 - 1402
反应条件
1: 85.5 percent / H2 / Pd/CaCO3 / methanol / 1 h
2: 18 percent / H2N-NH2*H2O / methanol; H2O / 48 h / Ambient temperature
3: 94 percent / K-OCMe3 / dioxane; methanol / Ambient temperature
4: 85 percent / CH2Cl2 / 3.5 h / Irradiation
View Scheme
参考文献
Maier, Guenther; Schneider, Manfred; Kreiling, Gerda; Mayer, Wolfram
Chemische Berichte, 1981 , vol. 114, p. 3922 - 3934
反应条件
in chloroform-d1
T=-60 - 20°C;
参考文献
Banert, Klaus; Koehler, Frank
Angewandte Chemie, International Edition, 2001 , vol. 40, # 1 p. 174 - 177
Angewandte Chemie, 2001 , vol. 113, p. 173 - 176
反应条件
1: 18 percent / H2N-NH2*H2O / methanol; H2O / 48 h / Ambient temperature
2: 94 percent / K-OCMe3 / dioxane; methanol / Ambient temperature
3: 85 percent / CH2Cl2 / 3.5 h / Irradiation
View Scheme
参考文献
Maier, Guenther; Schneider, Manfred; Kreiling, Gerda; Mayer, Wolfram
Chemische Berichte, 1981 , vol. 114, p. 3922 - 3934
反应条件
(NH4)2S2O8; silver nitrate
1.) 10 percent aq. H2SO4, 90 deg C, 1 h, 2.) 10 percent aq. H2SO4, 90 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Heinisch, Gottfried; Loutsch, Gerhard
Heterocycles, 1984 , vol. 22, # 6 p. 1395 - 1402
反应条件
1: 35 percent / triphenylphosphane / benzene / Heating
2: 65 percent / H2N-NH2*H2O / acetic acid / 10 h / Ambient temperature
View Scheme
参考文献
Maier, Guenther; Schneider, Manfred; Kreiling, Gerda; Mayer, Wolfram
Chemische Berichte, 1981 , vol. 114, p. 3922 - 3934
反应条件
1: 94 percent / K-OCMe3 / dioxane; methanol / Ambient temperature
2: 85 percent / CH2Cl2 / 3.5 h / Irradiation
View Scheme
参考文献
Maier, Guenther; Schneider, Manfred; Kreiling, Gerda; Mayer, Wolfram
Chemische Berichte, 1981 , vol. 114, p. 3922 - 3934
反应条件
in acetonitrile-D3
T=-40°C; Photolysis;
参考文献
Banert, Klaus; Grimme, Stefan; Herges, Rainer; Hess, Kirsten; Koehler, Frank; Mueck-Lichtenfeld, Christian; Wuerthwein, Ernst-Ulrich
Chemistry - A European Journal, 2006 , vol. 12, # 28 p. 7467 - 7481
反应条件
(NH4)2S2O8; silver nitrate in sulfuric acid
T=90°C; 1 h; other 1,2-diazines, other source of methyl radical; Product distribution;
参考文献
Heinisch, Gottfried; Loutsch, Gerhard
Heterocycles, 1984 , vol. 22, # 6 p. 1395 - 1402
反应条件
hydrazine hydrate; lead dioxide
1.) EtOH, 25 deg C, 1h, 2.) 60 deg C, 3h; Yield given. Multistep reaction;
参考文献
Shepherd, Michael K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 961 - 970
