N-CBZ-beta-丙氨酸合成路线 （共 48 条）
反应条件
sulfuric acid; magnesium sulfate in dichloromethane T=25°C; 18 h;
参考文献
Tetrahedron Letters, , vol. 38, # 42 p. 7345 - 7348
反应条件
N-benzyl-N,N,N-triethylammonium chloride in N,N-dimethyl acetamide T=55°C;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 20 p. 3199 - 3202
反应条件
sulfuric acid in dichloromethane
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 10, p. 1219 - 1224
反应条件
in benzene 0.5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 7 p. 1497 - 1503
反应条件
sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=20°C;
参考文献
Xue, Chu-Biao; He, Xiaohua; Roderick, John; Corbett, Ronald L.; Decicco, Carl P.
Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 865 - 870
反应条件
1: With camphor-10-sulfonic acid 15 h; Heating; 2: With diisobutylaluminium hydride in hexane; dichloromethane T=-78°C; 2 h;
参考文献
Iwata-Reuyl, Dirk; Basak, Amit; Townsend, Craig A.
Journal of the American Chemical Society, 1999 , vol. 121, # 49 p. 11356 - 11368
反应条件
1: tributylamine / tetrahydrofuran / 0.17 h / -20 °C 2: 152 mg / aq. NH3 / tetrahydrofuran / 1 h / 0 °C 3: pyridine; [bis(trifluoroacetoxy)iodo]benzene / dimethylformamide; H2O / 3 h / 0 - 20 °C 4: 304 mg / NaHCO3 / dioxane; H2O / 0 - 20 °C View Scheme
参考文献
Wakamiya, Tateaki; Kamata, Makoto; Kusumoto, Shoichi; Kobayashi, Hiroyuki; Sai, Yoshimichi; Tamai, Ikumi; Tsuji, Akira
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 3 p. 699 - 709
反应条件
1: tributylamine / tetrahydrofuran / 0.17 h / -20 °C 2: 152 mg / aq. NH3 / tetrahydrofuran / 1 h / 0 °C 3: pyridine; [bis(trifluoroacetoxy)iodo]benzene / dimethylformamide; H2O / 3 h / 0 - 20 °C View Scheme
参考文献
Wakamiya, Tateaki; Kamata, Makoto; Kusumoto, Shoichi; Kobayashi, Hiroyuki; Sai, Yoshimichi; Tamai, Ikumi; Tsuji, Akira
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 3 p. 699 - 709
反应条件
dicyclohexyl-carbodiimide in ethyl acetate
参考文献
Flouret; Cole; Biemacher
Journal of medicinal chemistry, 1972 , vol. 15, # 12 p. 1281 - 1283
反应条件
triethylamine; dicyclohexyl-carbodiimide
参考文献
Nakao,Y. et al.
Bulletin of the Chemical Society of Japan, 1970 , vol. 43, # 11 p. 3457 - 3461
