1-(2-氨基-5-甲氧基苯基)-乙酮合成路线 （共 31 条）
反应条件
1: 88 percent / tetrahydrofuran / 1.) -50 deg C, 4 h, 2.) r.t., 1 h
2: 88 percent / PDC / CH2Cl2 / 6 h / Heating
3: 97 percent / H2 / 5percent Pd/C / ethanol / 3 h / 760 Torr
View Scheme
参考文献
Fuerstner, Alois; Jumbam, Denis N.; Seidel, Guenter
Chemische Berichte, 1994 , vol. 127, # 6 p. 1125 - 1130
反应条件
1: 88 percent / PDC / CH2Cl2 / 6 h / Heating
2: 97 percent / H2 / 5percent Pd/C / ethanol / 3 h / 760 Torr
View Scheme
参考文献
Fuerstner, Alois; Jumbam, Denis N.; Seidel, Guenter
Chemische Berichte, 1994 , vol. 127, # 6 p. 1125 - 1130
反应条件
ytterbium trifluoromethanesulfonate; lithium perchlorate in nitromethane
T=100°C; Fries rearrangement; 8 h;
参考文献
Su, Weike; Jin, Can
Journal of Chemical Research, 2004 , # 9 p. 611 - 613
反应条件
1: With silver hexafluoroantimonate; {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; copper (II) acetate monohydrate in 1,2-dichloro-ethane
T=100°C; 24 h; Inert atmosphereSchlenk technique;
2: With sulfuric acid
T=0 - 20°C; 2 h; Inert atmosphereSchlenk technique;
3: With sodium hydrogencarbonate
Inert atmosphereSchlenk technique;
参考文献
Bhanuchandra; Ramu Yadav; Rit, Raja K.; Rao Kuram, Malleswara; Sahoo, Akhila K.
Chemical Communications, 2013 , vol. 49, # 45 p. 5225 - 5227
反应条件
1: aqueous NaOH
2: iron-powder; aqueous acetic acid
View Scheme
参考文献
Osborn; Schofield
Journal of the Chemical Society, 1955 , p. 2100,2102
反应条件
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 °C
2.2: 20 °C
3.1: tetrahydrofuran / -78 - 20 °C
4.1: 10 palladium on activated charcoal; hydrogen / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
Desrat, Sandy; Jean, Mickael; Van De Weghe, Pierre
Tetrahedron, 2011 , vol. 67, # 39 p. 7510 - 7516
反应条件
1: tetrahydrofuran / -78 - 20 °C
2: 10 palladium on activated charcoal; hydrogen / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
Desrat, Sandy; Jean, Mickael; Van De Weghe, Pierre
Tetrahedron, 2011 , vol. 67, # 39 p. 7510 - 7516
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 °C
1.2: 20 °C
2.1: tetrahydrofuran / -78 - 20 °C
3.1: 10 palladium on activated charcoal; hydrogen / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
Desrat, Sandy; Jean, Mickael; Van De Weghe, Pierre
Tetrahedron, 2011 , vol. 67, # 39 p. 7510 - 7516
反应条件
1.1: potassium carbonate / tetrahydrofuran / 24 h / 50 °C
2.1: potassium carbonate / acetone / 4 h / Reflux
3.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 °C
3.2: 20 °C
4.1: tetrahydrofuran / -78 - 20 °C
5.1: 10 palladium on activated charcoal; hydrogen / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
Desrat, Sandy; Jean, Mickael; Van De Weghe, Pierre
Tetrahedron, 2011 , vol. 67, # 39 p. 7510 - 7516
反应条件
in acetonitrile
T=20°C; Fries rearrangement; 20 h; Inert atmosphereUV-irradiation;
参考文献
Guerrini, Giacomo; Taddei, Maurizio; Ponticelli, Fabio
Journal of Organic Chemistry, 2011 , vol. 76, # 18 p. 7597 - 7601
