3-异丁氧基-2-环己烯酮合成路线 （共 19 条）
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
1.2: 77 percent / tetrahydrofuran / 6 h / Heating
2.1: aqueous HCl / acetone / 8 h / 20 °C
View Scheme
参考文献
Gulias, Moises; Rodriguez, J. Ramon; Castedo, Luis; Mascarenas, Jose L.
Organic Letters, 2003 , vol. 5, # 11 p. 1975 - 1977
反应条件
sodium hydride in diethyl ether
参考文献
Varseev, Georgy N.; Maier, Martin E.
Angewandte Chemie, International Edition, 2009 , vol. 48, # 20 p. 3685 - 3688
反应条件
1: in diethyl ether; hexane
T=20°C; 0.5 h;
2: With sulfuric acid in diethyl ether; hexane; water
参考文献
Kyte, Brian G.; Rouviere, Pierre; Cheng, Qiong; Stewart, Jon D.
Journal of Organic Chemistry, 2004 , vol. 69, # 1 p. 12 - 17
反应条件
1: in diethyl ether
T=20°C; 0.5 h;
2: With sulfuric acid in tetrahydrofuran; diethyl ether; water
参考文献
Kyte, Brian G.; Rouviere, Pierre; Cheng, Qiong; Stewart, Jon D.
Journal of Organic Chemistry, 2004 , vol. 69, # 1 p. 12 - 17
反应条件
1: in diethyl ether
T=20°C; 0.5 h;
2: With sulfuric acid in diethyl ether; water
参考文献
Kyte, Brian G.; Rouviere, Pierre; Cheng, Qiong; Stewart, Jon D.
Journal of Organic Chemistry, 2004 , vol. 69, # 1 p. 12 - 17
反应条件
tetrahydrofuran; diethyl ether; vinyl-magnesium bromide
anschl. mit wss. H2SO4;
参考文献
Crisan; Normant
Bulletin de la Societe Chimique de France, 1957 , p. 1451,1453
反应条件
sulfuric acid
1.) THF, 0 deg C; Yield given. Multistep reaction;
参考文献
Nagashima, Shigeru; Taishi, Teruhiko; Kanematsu, Ken
Heterocycles, 1994 , vol. 39, # 1 p. 55 - 58
反应条件
1: 3-(2-methylpropoxy)cyclohex-2-en-1-one With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-80°C; 1 h; Inert atmosphere;
2: allyl bromide in tetrahydrofuran; hexane
T=-80 - 20°C; 12 h; Inert atmosphere;
参考文献
Varseev, Georgy N.; Maier, Martin E.
Angewandte Chemie, International Edition, 2009 , vol. 48, # 20 p. 3685 - 3688
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
1.2: 77 percent / tetrahydrofuran / -78 - 20 °C
2.1: aqueous HCl / acetone / 8 h / 20 °C
3.1: 90 percent / W(CO)6 / tetrahydrofuran / 20 °C / UV-irradiation
View Scheme
参考文献
Gulias, Moises; Rodriguez, J. Ramon; Castedo, Luis; Mascarenas, Jose L.
Organic Letters, 2003 , vol. 5, # 11 p. 1975 - 1977
