6-乙酰氧基-4-氯-7-甲氧基喹唑啉合成路线 （共 17 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in 1,2-dichloro-ethane 3 h; Heating / reflux;
参考文献
ARRAY BIOPHARMA, INC.
Patent: WO2004/46101 A2, 2004 ;
Location in patent: Page 38-39 ;
WO 2004/046101 A2
反应条件
in DMF (N,N-dimethyl-formamide) 5 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2004/105765 A1, 2004 ;
Location in patent: Page 90 ;
WO 2004/105765 A1
反应条件
1.1: 45 percent / methionine; MeSO3H / 3 h / 100 °C 2.1: pyridine / 100 °C 2.2: 70 percent / SOCl2 / 16 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 45 p. 7715 - 7719
反应条件
in 1,2-dichloro-ethane 3 h; Heating / reflux;
参考文献
Wallace, Eli; Topolov, George; Zhao, Qian; Lyssikatos, Joseph P.
Patent: US2005/101617 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
1: With pyridine T=100°C; 2: With thionyl chloride 16 h; Heating;
参考文献
Harris, Craig S.; Hennequin, Laurent F.; Kettle, Jason G.; Willerval, Olivier A.
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7715 - 7719
反应条件
1: pyridine 2: SOCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1911 - 1914
反应条件
1: 180 °C 2: 1.) methionine, MeSO3H / 1.) 100 deg C, 3 h, 2.) Py 3: SOCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 21 p. 2723 - 2728
反应条件
1: 160 - 170 °C 2: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 3: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 4: trichlorophosphate / toluene / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
1: 10 palladium on activated charcoal; hydrogen 2: 160 - 170 °C 3: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 4: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 5: trichlorophosphate / toluene / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 5: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 6: trichlorophosphate / toluene / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
