1,2-二氯-4-氟-5-硝基苯合成路线 （共 11 条）
反应条件
sulfuric acid; nitric acid
参考文献
Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
反应条件
fluoride Substitution;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # SUPPL. 1 p. S27-S29
反应条件
in N,N-dimethyl-formamide; toluene
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/309738 A1, 2012 ;
Location in patent: Page/Page column 25 ;
US 20120309738 A1
反应条件
1: With iron; acetic acid in water T=100°C; 0.5 h; Inert atmosphere; 2: With sodium hydrogencarbonate in water T=10°C; pH=8 - 9;
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; GREENE, Mark, I.; ZHANG, Hongtao; BEREZOV, Alan; CAI, Zheng
Patent: WO2012/125913 A1, 2012 ;
Location in patent: Page/Page column 42; 43 ;
反应条件
hydrazine hydrate in EtOH-water; ethyl alcohol water
参考文献
Hadasit Medical Research Services and Development Ltd.
Patent: US6126917 A1, 2000 ;
US 6126917 A
反应条件
1: 97 percent / NaH / dimethylsulfoxide / 100 °C 2: 95 percent / Sn, HCl / ethanol / Heating View Scheme
参考文献
Kraynack, Erica A.; Dalgard, Jackline E.; Gaeta, Federico C. A.
Tetrahedron Letters, 1998 , vol. 39, # 42 p. 7679 - 7682
反应条件
1: 97 percent / NaH / dimethylsulfoxide / 100 °C 2: 95 percent / Sn, HCl / ethanol / Heating 3: pyridine*HBr*Br2 / 2-methyl-propan-2-ol; H2O / 16 h 4: 70 percent / H2O / methanol / 50 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 42 p. 7679 - 7682
反应条件
potassium carbonate in dichloromethane; water
T=20°C; 14 h;
参考文献
Seth, Punit P.; Robinson, Dale E.; Jefferson, Elizabeth A.; Swayze, Eric E.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7303 - 7306
反应条件
1: K2CO3 / CH2Cl2; H2O / 14 h / 20 °C
2: H2 / Raney Ni / 5 h / 20 °C
View Scheme
参考文献
Seth, Punit P.; Robinson, Dale E.; Jefferson, Elizabeth A.; Swayze, Eric E.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7303 - 7306
反应条件
1: air / methanol / 25 °C
View Scheme
参考文献
Krchnak, Viktor; Szabo, Lajos; Vagner, Josef
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2835 - 2838
