4-羟基-3-苯基-2(5H)-呋喃酮合成路线 （共 10 条）
反应条件
sodium hydride in tetrahydrofuran
T=20°C;
参考文献
Weber, Valerie; Rubat, Catherine; Duroux, Eliane; Lartigue, Claire; Madesclaire, Michel; Coudert, Pascal
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 14 p. 4552 - 4564
反应条件
potassium tert-butylate in tetrahydrofuran
16 h; Heating;
参考文献
Mallinger, Aurelie; Gall, Thierry Le; Mioskowski, Charles
Journal of Organic Chemistry, 2009 , vol. 74, # 3 p. 1124 - 1129
反应条件
1: With potassium carbonate in acetone
T=20°C; 6 h;
2: With potassium tert-butylate in tetrahydrofuran
Dieckmann reaction; Inert atmosphereReflux;
参考文献
Yang, Wanqiu; Liu, Jikai; Zhang, Hongbin
Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4874 - 4876
反应条件
1: 774 g / sodium ethoxide / ethanol / 4 h / Heating
2: 446 g / potassium t-butoxide / 2-methyl-propan-2-ol / 1 h / Heating
View Scheme
参考文献
Campbell, Alexander C.; Maidment, Maurice S.; Pick, John H.; Stevenson, Donald F. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1567 - 1576
反应条件
sodium in ethanol
20 h; sealed system;
参考文献
Campbell, Alexander C.; Maidment, Maurice S.; Pick, John H.; Stevenson, Donald F. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1567 - 1576
反应条件
4-methylene-oxetan-2-one; dirhodium tetraacetate
T=20°C; Decarboxylation; Insertion; 48 h;
参考文献
Murphy, Paul V.; O'Sullivan, Timothy J.; Kennedy, Bryan D.; Geraghty, Niall W.A.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 13 p. 2121 - 2126
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight; Yield given. Multistep reaction;
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1539 - 1545
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight; Yield given. Multistep reaction;
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1539 - 1545
反应条件
sodium ethanolate in ethanol
1.5 h; Ambient temperature; Yield given;
参考文献
Campbell, Alexander C.; Maidment, Maurice S.; Pick, John H.; Stevenson, Donald F. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1567 - 1576
反应条件
potassium carbonate in acetone
T=20°C; Inert atmosphere;
参考文献
Xu, Hai-Wei; Xu, Chao; Fan, Zi-Qi; Zhao, Ling-Jie; Liu, Hong-Min
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 737 - 739
