4-甲氧基苯基(3-吡啶基)甲酮合成路线 （共 10 条）
反应条件
1: 3-iodo-pyridine; (4-methoxyphenyl)-boronic acid With Pd(2,2,6,6-tetrametyl-3,5-heptanedionate)2; potassium carbonate in toluene Suzuki coupling reaction; 0.166667 h; 2: carbon monoxide in toluene T=100°C; Suzuki coupling reaction; P=10343.2 Torr; 10 h;
参考文献
Tambade, Pawan J.; Patil, Yogesh P.; Panda, Anil G.; Bhanage, Bhalchandra M.
European Journal of Organic Chemistry, 2009 , # 18 p. 3022 - 3025
反应条件
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate in methoxybenzene T=100°C; Suzuki carbonylative coupling; P=760.051 Torr; 20 h; chemoselective reaction;
参考文献
Li, Hongling; Yang, Min; Qi, Yanxing; Xue, Jijun
European Journal of Organic Chemistry, 2011 , # 14 p. 2662 - 2667
反应条件
aluminium trichloride in 1,2-dichloro-ethane T=80°C; 0.3 h;
参考文献
Langhals, Elke; Langhals, Heinz; Ruechardt, Christoph
Liebigs Annalen der Chemie, 1982 , # 5 p. 930 - 949
反应条件
T=210 - 220°C; P=5 Torr; 0.5 h;
参考文献
Youssef, Mohamed Salah K.; Fahmy, Amin F.; Abdel Halim, Mohamed S.; Hassan, Mamdouh A.; Sauer, Juergen
Organic Preparations and Procedures International, 2005 , vol. 37, # 3 p. 247 - 256
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine 1.) CH2Cl2, -70 deg C, 45 min, 2.) CH2Cl2, from -70 deg C to 25 deg C; Multistep reaction;
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
1: 1.) n-BuLi / 1.) Et2O, hexane, -70 deg C, 2.) Et2O, hexane, THF, -70 deg C, 1 h 2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 45 min, 2.) CH2Cl2, from -70 deg C to 25 deg C View Scheme
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
1: 1.) n-BuLi / 1.) Et2O, hexane, -70 deg C, 2.) Et2O, hexane, THF, -70 deg C, 1 h 2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 45 min, 2.) CH2Cl2, from -70 deg C to 25 deg C View Scheme
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
1: 71 percent / anhydrous aluminum chloride / 6 h / 80 °C 2: 0.5 h / 210 - 220 °C / 5 Torr View Scheme
参考文献
Youssef, Mohamed Salah K.; Fahmy, Amin F.; Abdel Halim, Mohamed S.; Hassan, Mamdouh A.; Sauer, Juergen
Organic Preparations and Procedures International, 2005 , vol. 37, # 3 p. 247 - 256
反应条件
1: 71 percent / anhydrous aluminum chloride / 6 h / 80 °C 2: 0.5 h / 210 - 220 °C / 5 Torr View Scheme
参考文献
Youssef, Mohamed Salah K.; Fahmy, Amin F.; Abdel Halim, Mohamed S.; Hassan, Mamdouh A.; Sauer, Juergen
Organic Preparations and Procedures International, 2005 , vol. 37, # 3 p. 247 - 256
反应条件
magnesium 1) ether; Yield given. Multistep reaction;
参考文献
Schwarz; Hartmann; Schonenberger
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 223 - 229
