2-氨基-5,6,7,8-四氢-4H-环庚基[b]噻吩-3-甲腈合成路线 （共 7 条）
反应条件
morpholine; sulfur in ethanol T=70°C; 17 h;
参考文献
SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED
Patent: WO2005/44008 A2, 2005 ;
Location in patent: Page/Page column 93 ;
反应条件
sulfur; Et4NPF6; acetonitrile T=20°C; Gewald reaction; ElectrolysisInert atmosphere;
参考文献
Feroci, Marta; Chiarotto, Isabella; Rossi, Leucio; Inesi, Achille
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2740 - 2746
反应条件
PPA; phosphoric acid T=110 - 120°C; 5 h;
参考文献
Offermann; Eger; Roth
Archiv der Pharmazie, 1981 , vol. 314, # 2 p. 168 - 175
反应条件
1: 67 percent / conc. aq. HCl / 12 h / Heating 2: 71 percent / POCl3 / dioxane / 3 h / Heating View Scheme
参考文献
El-Gazzar; Hegab; Swelam; Aly
Phosphorus, Sulfur and Silicon and Related Elements, 2002 , vol. 177, # 1 p. 123 - 136
参考文献
El-Gazzar; Hegab; Swelam; Aly
Phosphorus, Sulfur and Silicon and Related Elements, 2002 , vol. 177, # 1 p. 123 - 136
反应条件
1: 67 percent / conc. aq. HCl / 12 h / Heating
2: 71 percent / POCl3 / dioxane / 3 h / Heating
3: 79 percent / hydrazine hydrate / dioxane / 5 h / Heating
View Scheme
参考文献
El-Gazzar; Hegab; Swelam; Aly
Phosphorus, Sulfur and Silicon and Related Elements, 2002 , vol. 177, # 1 p. 123 - 136
反应条件
hydrogenchloride
12 h; Heating;
参考文献
El-Gazzar; Hegab; Swelam; Aly
Phosphorus, Sulfur and Silicon and Related Elements, 2002 , vol. 177, # 1 p. 123 - 136
