2-(6-甲氧基-2-萘基)丙酸合成路线 （共 130 条）
反应条件
(-)-(S)-β-Np-BTM; 4-methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Onda, Yu-Suke; Itagaki, Makoto
Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11629 - 11641
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 6 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Nakata, Kenya; Onda, Yu-Suke; Ono, Keisuke; Shiina, Isamu
Tetrahedron Letters, 2010 , vol. 51, # 43 p. 5666 - 5669
参考文献
Bellucci, Giuseppe; Berti, Giancarlo; Bianchini, Roberto; Vecchiani, Sandra
Gazzetta Chimica Italiana, 1988 , vol. 118, # 6 p. 451 - 456
反应条件
1-deoxy-1-(octylamino)-d-glucitol in acetonitrile 6 h; Heating;
参考文献
Yuan, Xuejun; Li, Jiguo; Tian, Yunqi; Lee, Gene-Hsiang; Peng, Xie-Ming; Zhu, Rongguang; You, Xiaozeng
Tetrahedron Asymmetry, 2001 , vol. 12, # 21 p. 3015 - 3018
反应条件
Novozym 435reg; in acetonitrile T=45°C; 72 h; Resolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Morrone; D'Antona; Lambusta; Nicolosi
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 65, # 1-4 p. 49 - 51
参考文献
A. H. Robins Company, Incorporated
Patent: US5192785 A1, 1993 ;
参考文献
A. H. Robins Company, Incorporated
Patent: US5194446 A1, 1993 ;
反应条件
lithium aluminium tetrahydride
参考文献
Annunziata, Rita; Cinquino, Mauro; Cozzi, Franco; Raimondi, Laura; Stefanelli, Stefania
Tetrahedron, 1986 , vol. 42, # 19 p. 5443 - 5450
反应条件
1: LiAlH4
2: Swern oxidation
View Scheme
参考文献
Annunziata, Rita; Cinquino, Mauro; Cozzi, Franco; Raimondi, Laura; Stefanelli, Stefania
Tetrahedron, 1986 , vol. 42, # 19 p. 5443 - 5450
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / 0 °C
1.2: tetrahydrofuran / 2 h / 0 - 20 °C
2.1: (R)-BINOL-SnCl4 / toluene; CH2Cl2 / 1 h / -78 °C
2.2: aq. HCl / toluene; CH2Cl2
View Scheme
参考文献
Svoboda, Jiri; Capek, Karel; Palecek, Jaroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 3 p. 766 - 774
