in neat (no solvent)
all manipulations under Ar; solvochemically tin metal and 5 eqiuvalents of alkyl bromide heated at 95°C for 60 min; excess alkyl bromide removed in vac., chromy., recrystd. from THF/CHCl3;
1: 6-aminopurine With sodium hydride in N,N-dimethyl-formamide
T=80°C; 1 h;
2: 1-bromo-2-cyanoethane in N,N-dimethyl-formamide
T=65°C; 17 h; Further stages.;
参考文献
Hakimelahi; Tai Wei Ly; Moosavi-Movahedi; Jain; Zakerinia; Davari; Mei; Sambaiah; Moshfegh
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3710 - 3720
Kiasat, Ali Reza; Mokhtari, Babak; Savari, Ali; Kazemi, Foad
Phosphorus, Sulfur and Silicon and the Related Elements, 2008 , vol. 183, # 1 p. 178 - 182
1: indole With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C; 0.5 h;
2: 1-bromo-2-cyanoethane in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C;
参考文献
Zeng, Fanlong; Alper, Howard
Organic Letters, 2013 , vol. 15, # 8 p. 2034 - 2037
