2-氨基-3,5-二溴吡嗪合成路线 （共 54 条）
反应条件
bromine; sodium hydrogencarbonate in acetic acid 1.) 2h, 2.) 1h;
参考文献
Paudler, William W.; Jovanovic, Misa V.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1064 - 1069
反应条件
N-bromosuccinmide in dichloromethane T=0 - 5°C; 2 h;
参考文献
Chemical Communications, , vol. 47, # 16 p. 4688 - 4690
反应条件
pyridine; bromine in chloroform 3 h; Ambient temperature1.1 equivalent bromine and pyridine;
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 673 - 674
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0°C; 1 h; Overall yield = 75 percent; Overall yield = 2 g;
参考文献
Heterocycles, , vol. 86, # 2 p. 1323 - 1339
反应条件
palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine in dimethyl sulfoxide regioselective reaction;
参考文献
Itoh, Takahiro; Kato, Shinji; Nonoyama, Nobuaki; Wada, Toshihiro; Maeda, Kenji; Mase, Toshiaki; Zhao, Matthew M.; Song, Jake Z.; Tschaen, David M.; McNamara, James M.
Organic Process Research and Development, 2006 , vol. 10, # 4 p. 822 - 828
参考文献
Alcon, Inc.
Patent: US2006/142307 A1, 2006 ;
Location in patent: Page/Page column 5; 10 ;
US 20060142307 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran T=-5 - 0°C; 1.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 3 p. 693 - 698
反应条件
in ethanol; dimethyl amine
参考文献
Zeneca Limited
Patent: US5861401 A1, 1999 ;
参考文献
l'Universite de Montpellier I
Patent: US5028605 A1, 1991 ;
反应条件
ammonium hydroxide in water T=110°C; 16 h; sealed tube;
参考文献
de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael
Patent: US2011/59118 A1, 2011 ;
Location in patent: Page/Page column 81-82 ;
