1-噁-3-氮杂螺[4.5]-2-癸酮合成路线 （共 8 条）
反应条件
1: 1-aminomethyl-1-cyclohexanol hydrochloride With triethylamine in dichloromethane
0.25 h;
2: carbonic acid di-pyridin-2-yl ester in dichloromethane
T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2008/32191 A2, 2008 ;
Location in patent: Page/Page column 44-45 ;
WO 2008/032191 A2
反应条件
sodium azide; iodobenzene dichloride in ethyl acetate
T=0 - 80°C; Curtius Rearrangement; 12 h; Inert atmosphere;
参考文献
He, Tian; Gao, Wen-Chao; Wang, Wei-Kun; Zhang, Chi
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1113 - 1118
反应条件
1H-imidazole in dichloromethane
12 h; Ambient temperature;
参考文献
Geffken, Detlef
Liebigs Annalen der Chemie, 1982 , # 2 p. 219 - 225
反应条件
hydrogenchloride; Petroleum ether; sodium nitrite
anschliessend Erwaermen;
参考文献
Newman; Kutner
Journal of the American Chemical Society, 1951 , vol. 73, p. 4199,4202
参考文献
Harnden,M.R.; Rasmussen,R.R.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 305 - 308
反应条件
1: NaOMe, NaOAc / methanol
2: H2O / 4 h / 100 °C
View Scheme
参考文献
Harnden,M.R.; Rasmussen,R.R.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 305 - 308
反应条件
1: zinc; chloro-trimethyl-silane / tetrahydrofuran / |Inert atmosphere; |Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3: iodobenzene dichloride; sodium azide / ethyl acetate / 12 h / 0 - 80 °C / |Inert atmosphere
View Scheme
参考文献
He, Tian; Gao, Wen-Chao; Wang, Wei-Kun; Zhang, Chi
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1113 - 1118
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: iodobenzene dichloride; sodium azide / ethyl acetate / 12 h / 0 - 80 °C / |Inert atmosphere
View Scheme
参考文献
He, Tian; Gao, Wen-Chao; Wang, Wei-Kun; Zhang, Chi
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1113 - 1118
