2-氯-5,5-二甲基-1,3,2-二氧磷杂环己烷合成路线 （共 28 条）
反应条件
1: 75 percent / Na / dioxane / 24 h / 20 °C
2: -50 °C
View Scheme
参考文献
Iorish, V. Yu.; Grachev, M. K.; Bekker, A. R.; Nifant'ev, E. E.
J. Gen. Chem. USSR (Engl. Transl.), 1991 , vol. 61, # 1.1 p. 92 - 99
参考文献
Chakravarty, Manab; Srinivas; Muthiah; Kumara Swamy
Synthesis, 2003 , # 15 p. 2368 - 2372
反应条件
1: triethylamine / tetrahydrofuran / 1 h / Ambient temperature
2: 82 percent / 3 h / 95 °C
View Scheme
参考文献
Edmundson,R.S.
Tetrahedron, 1964 , vol. 20, p. 2781 - 2795
反应条件
1: 90 percent / triethylamine / toluene / 0.5 h / 0 °C
2: ozone / toluene; CH2Cl2 / -78 °C
3: toluene; CH2Cl2 / -50 °C
View Scheme
参考文献
Khatib, F. el; Caminade, A. M.; Koenig, M.
Phosphorus and Sulfur and the Related Elements, 1984 , vol. 20, p. 55 - 66
反应条件
1: Et3N / benzene
2: tBuO2H
View Scheme
参考文献
Stec,W.J. et al.
Journal of Organic Chemistry, 1976 , vol. 41, # 2 p. 227 - 233
反应条件
1: (E)-1-(4-methoxyphenyl)ethanone oxime With water; triethylamine in toluene
T=0°C; Beckmann Rearrangement; 0.25 h; Inert atmosphere;
2: 4-toluenesulfonyl azide; 2-chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane in toluene
T=0 - 20°C; 2.5 h; Inert atmosphere; Reagent/catalyst; Overall yield = 58 percent; Overall yield = 87.4 mg; chemoselective reaction;
参考文献
Fleury, Lauren M.; Wilson, Erin E.; Vogt, Monika; Fan, Tiffany J.; Oliver, Allen G.; Ashfeld, Brandon L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11589 - 11593
Angew. Chem., 2013 , vol. 125, # 44 p. 11803 - 11807,5
参考文献
Mikolajczyk,J. et al.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1973 , vol. 28, p. 620 - 624
反应条件
in benzene
T=20°C; 4 h;
参考文献
Gratchev, M. K.; Kurochkina, G. I.; Negrebetsky, V. V.; Nifantyev, E. E.
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 88, # 1-4 p. 257 - 270
